Literature DB >> 24815508

Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors.

Jianyang Chen1, Haixia Peng1, Jinxue He2, Xiajuan Huan2, Zehong Miao3, Chunhao Yang4.   

Abstract

The isoquinolinone-based tricyclic compounds were designed and synthesized. Preliminary biological study of these compounds provided potent compounds 17a, 33b, 33c, 33d, and 33g with low nanomolar IC50s against PARP-1 enzyme.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antitumor; Isoquinolinone-based tricycles; PARP-1 inhibitors

Mesh：

Substances：

Year:  2014        PMID： 24815508     DOI： 10.1016/j.bmcl.2014.04.061

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Active site fingerprinting and pharmacophore screening strategies for the identification of dual inhibitors of protein kinase C (ΡΚCβ) and poly (ADP-ribose) polymerase-1 (PARP-1).

Authors:  Navriti Chadha; Om Silakari
Journal:  Mol Divers       Date:  2016-05-23       Impact factor: 2.943

2.  Diversity-oriented functionalization of 2-pyridones and uracils.

Authors:  Yong Shang; Chenggui Wu; Qianwen Gao; Chang Liu; Lisha Li; Xinping Zhang; Hong-Gang Cheng; Shanshan Liu; Qianghui Zhou
Journal:  Nat Commun       Date:  2021-05-20       Impact factor: 14.919

3.  Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution.

Authors:  Jin-Xue He; Meng Wang; Xia-Juan Huan; Chuan-Huizi Chen; Shan-Shan Song; Ying-Qing Wang; Xue-Mei Liao; Cun Tan; Qian He; Lin-Jiang Tong; Yu-Ting Wang; Xiao-Hua Li; Yi Su; Yan-Yan Shen; Yi-Ming Sun; Xin-Ying Yang; Yi Chen; Zhi-Wei Gao; Xiao-Yan Chen; Bing Xiong; Xiu-Lian Lu; Jian Ding; Chun-Hao Yang; Ze-Hong Miao
Journal:  Oncotarget       Date:  2017-01-17

4.  Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter.

Authors:  Yu-Nan Tian; Hua-Dong Chen; Chang-Qing Tian; Ying-Qing Wang; Ze-Hong Miao
Journal:  Cell Death Dis       Date:  2020-01-28       Impact factor: 8.469

Review 5.  Recent Advances in One-Pot Modular Synthesis of 2-Quinolones.

Authors:  Wan Pyo Hong; Inji Shin; Hee Nam Lim
Journal:  Molecules       Date:  2020-11-20       Impact factor: 4.411

6.  Repeated treatments of Capan-1 cells with PARP1 and Chk1 inhibitors promote drug resistance, migration and invasion.

Authors:  Ne Guo; Meng-Zhu Li; Li-Min Wang; Hua-Dong Chen; Shan-Shan Song; Ze-Hong Miao; Jin-Xue He
Journal:  Cancer Biol Ther       Date:  2022-01-09       Impact factor: 4.742

7.  Fluzoparib increases radiation sensitivity of non-small cell lung cancer (NSCLC) cells without BRCA1/2 mutation, a novel PARP1 inhibitor undergoing clinical trials.

Authors:  Jing Luo; Xinchi Dai; Hua Hu; Jie Chen; Lujun Zhao; Changyong Yang; Jifeng Sun; Lianmin Zhang; Qian Wang; Shilei Xu; Yue Xu; Ningbo Liu; Guoguang Ying; Ping Wang
Journal:  J Cancer Res Clin Oncol       Date:  2019-11-30       Impact factor: 4.553
  7 in total

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