Literature DB >> 24815296

Wnt signaling and osteoporosis.

Stavros C Manolagas1.   

Abstract

Major advances in understanding basic bone biology and the cellular and molecular mechanisms responsible for the development of osteoporosis, over the last 20 years, have dramatically altered the management of this disease. The purpose of this mini-review is to highlight the seminal role of Wnt signaling in bone homeostasis and disease and the emergence of novel osteoporosis therapies by targeting Wnt signaling with drugs. Published by Elsevier Ireland Ltd.

Entities:  

Keywords:  Bone therapies; OPG; Osteoblasts; Osteoclasts; Osteocytes; RANKL

Mesh：

Substances：

Year:  2014        PMID： 24815296      PMCID： PMC4065196          DOI： 10.1016/j.maturitas.2014.04.013

Source DB:  PubMed          Journal:  Maturitas        ISSN： 0378-5122            Impact factor:   4.342


  42 in total

1.  Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study.

Authors:  Roger M D Zebaze; Ali Ghasem-Zadeh; Ann Bohte; Sandra Iuliano-Burns; Michiko Mirams; Roger Ian Price; Eleanor J Mackie; Ego Seeman
Journal:  Lancet       Date:  2010-05-15       Impact factor: 79.321

2.  Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength.

Authors:  Michael S Ominsky; Fay Vlasseros; Jacquelin Jolette; Susan Y Smith; Brian Stouch; George Doellgast; Jianhua Gong; Yongming Gao; Jin Cao; Kevin Graham; Barbara Tipton; Jill Cai; Rohini Deshpande; Lei Zhou; Michael D Hale; Daniel J Lightwood; Alistair J Henry; Andrew G Popplewell; Adrian R Moore; Martyn K Robinson; David L Lacey; W Scott Simonet; Chris Paszty
Journal:  J Bone Miner Res       Date:  2010-05       Impact factor: 6.741

Review 3.  What old means to bone.

Authors:  Stavros C Manolagas; A Michael Parfitt
Journal:  Trends Endocrinol Metab       Date:  2010-03-11       Impact factor: 12.015

4.  Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin.

Authors:  Wei Wei; Daniel Zeve; Jae Myoung Suh; Xueqian Wang; Yang Du; Joseph E Zerwekh; Paul C Dechow; Jonathan M Graff; Yihong Wan
Journal:  Mol Cell Biol       Date:  2011-08-29       Impact factor: 4.272

Review 5.  From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis.

Authors:  Stavros C Manolagas
Journal:  Endocr Rev       Date:  2010-01-05       Impact factor: 19.871

6.  Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis.

Authors:  Xiaodong Li; Michael S Ominsky; Kelly S Warmington; Sean Morony; Jianhua Gong; Jin Cao; Yongming Gao; Victoria Shalhoub; Barbara Tipton; Raj Haldankar; Qing Chen; Aaron Winters; Tom Boone; Zhaopo Geng; Qing-Tian Niu; Hua Zhu Ke; Paul J Kostenuik; W Scott Simonet; David L Lacey; Chris Paszty
Journal:  J Bone Miner Res       Date:  2009-04       Impact factor: 6.741

7.  Denosumab for prevention of fractures in postmenopausal women with osteoporosis.

Authors:  Steven R Cummings; Javier San Martin; Michael R McClung; Ethel S Siris; Richard Eastell; Ian R Reid; Pierre Delmas; Holly B Zoog; Matt Austin; Andrea Wang; Stepan Kutilek; Silvano Adami; Jose Zanchetta; Cesar Libanati; Suresh Siddhanti; Claus Christiansen
Journal:  N Engl J Med       Date:  2009-08-11       Impact factor: 91.245

Review 8.  The amazing osteocyte.

Authors:  Lynda F Bonewald
Journal:  J Bone Miner Res       Date:  2011-02       Impact factor: 6.741

9.  Matrix-embedded cells control osteoclast formation.

Authors:  Jinhu Xiong; Melda Onal; Robert L Jilka; Robert S Weinstein; Stavros C Manolagas; Charles A O'Brien
Journal:  Nat Med       Date:  2011-09-11       Impact factor: 53.440

10.  Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells.

Authors:  Jennifer R Stevens; Gustavo A Miranda-Carboni; Meredith A Singer; Sean M Brugger; Karen M Lyons; Timothy F Lane
Journal:  J Bone Miner Res       Date:  2010-10       Impact factor: 6.741
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  36 in total

1.  The Quest for Osteoporosis Mechanisms and Rational Therapies: How Far We've Come, How Much Further We Need to Go.

Authors:  Stavros C Manolagas
Journal:  J Bone Miner Res       Date:  2018-02-22       Impact factor: 6.741

2.  Treatment with intermittent PTH increases Wnt10b production by T cells in osteoporotic patients.

Authors:  P D'Amelio; F Sassi; I Buondonno; G Fornelli; E Spertino; L D'Amico; M Marchetti; M Lucchiari; I Roato; G C Isaia
Journal:  Osteoporos Int       Date:  2015-06-12       Impact factor: 4.507

Review 3.  Osteoimmunology: from mice to humans.

Authors:  Patrizia D'Amelio; Francesca Sassi
Journal:  Bonekey Rep       Date:  2016-05-18

4.  Featured Article: Transcriptional landscape analysis identifies differently expressed genes involved in follicle-stimulating hormone induced postmenopausal osteoporosis.

Authors:  Katre Maasalu; Ott Laius; Lidiia Zhytnik; Sulev Kõks; Ele Prans; Ene Reimann; Aare Märtson
Journal:  Exp Biol Med (Maywood)       Date:  2016-11-20

5.  Identifying potentially common genes between dyslipidemia and osteoporosis using novel analytical approaches.

Authors:  Xu Lin; Cheng Peng; Jonathan Greenbaum; Zhang-Fang Li; Ke-Hao Wu; Zeng-Xin Ao; Tong Zhang; Jie Shen; Hong-Wen Deng
Journal:  Mol Genet Genomics       Date:  2018-01-11       Impact factor: 3.291

6.  Osteoblastic NF-κB pathway is involved in 1α, 25(OH)2D3-induced osteoclast-like cells formation in vitro.

Authors:  Lin Cong; Chaoyi Zhang; Guanjun Tu
Journal:  Int J Clin Exp Pathol       Date:  2015-05-01

7.  The Wnt pathway regulator expression levels and their relationship to bone metabolism in thoracolumbar osteoporotic vertebral compression fracture patients.

Authors:  Xuefeng Ma; Xiaoqi Zhu; Xu He; Xiaobo Yi; Anmin Jin
Journal:  Am J Transl Res       Date:  2021-05-15       Impact factor: 4.060

8.  Treatment with soluble bone morphogenetic protein type 1A receptor fusion protein alleviates irradiation-induced bone loss in mice through increased bone formation and reduced bone resorption.

Authors:  Shen Wang; Jie Li; Huabei Sun; Liangwei Sha; Yilong Guo; Guanqiu Gu; Jiling Mao; Xinfa Nie; Ying Zhai; Dehong Yu; Juan Zhai; Hongnian Li; Xin Shan; Chengbai Dai; Xiangzhi Wu; Xiaobo He; Li Xin; Jun Liu; Ke Heng; Qinghe Geng
Journal:  Am J Transl Res       Date:  2020-03-15       Impact factor: 4.060

9.  Sclerostin Antibody Reverses the Severe Sublesional Bone Loss in Rats After Chronic Spinal Cord Injury.

Authors:  Wei Zhao; Xiaodong Li; Yuanzhen Peng; Yiwen Qin; Jiangping Pan; Jiliang Li; Aihua Xu; Michael S Ominsky; Christopher Cardozo; Jian Q Feng; Hua Zhu Ke; William A Bauman; Weiping Qin
Journal:  Calcif Tissue Int       Date:  2018-06-21       Impact factor: 4.333

10.  Genetic profiling of decreased bone mineral density in an independent sample of Caucasian women.

Authors:  X Xiao; D Roohani; Q Wu
Journal:  Osteoporos Int       Date:  2018-05-01       Impact factor: 4.507
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