M J Harrison1, M McCarthy2, C Fleming2, C Hickey2, C Shortt2, J A Eustace3, D M Murphy1, B J Plant4. 1. Cork Adult Cystic Fibrosis Centre, University College Cork, Cork University Hospital, Wilton, Cork, Ireland; HRB Clinical Research Facility, University College Cork, Cork, Ireland. 2. Cork Adult Cystic Fibrosis Centre, University College Cork, Cork University Hospital, Wilton, Cork, Ireland. 3. HRB Clinical Research Facility, University College Cork, Cork, Ireland. 4. Cork Adult Cystic Fibrosis Centre, University College Cork, Cork University Hospital, Wilton, Cork, Ireland; HRB Clinical Research Facility, University College Cork, Cork, Ireland. Electronic address: b.plant@ucc.ie.
Abstract
BACKGROUND: There are no published data on real-life clinical experience comparing inhaled antibiotic therapy via new rapid delivery systems with nebulised antibiotic therapy in CF. This real world study compares safety, effectiveness and tolerability using tobramycin inhaled powder (TIP) versus tobramycin inhaled solution (TIS). METHODS: Adult patients with CF commencing TIP (n=78) completed a questionnaire assessing safety, efficacy, tolerability, patient-satisfaction and self-reported adherence to TIS at baseline and during 12 months of TIP therapy. FEV1% predicted and exacerbation rate were recorded at each visit. RESULTS: There was a significant improvement in adherence scores, with a significant decrease in the number of intravenous antibiotic courses received during 12 months of TIP compared with the preceding 12 months using TIS. 94% of patients who had previously used TIS preferred TIP therapy over TIS. CONCLUSIONS: Inhaled powder tobramycin in CF is associated with improved adherence, tolerability and decreased exacerbation rates compared to nebulised treatment in real-life practice.
BACKGROUND: There are no published data on real-life clinical experience comparing inhaled antibiotic therapy via new rapid delivery systems with nebulised antibiotic therapy in CF. This real world study compares safety, effectiveness and tolerability using tobramycin inhaled powder (TIP) versus tobramycin inhaled solution (TIS). METHODS: Adult patients with CF commencing TIP (n=78) completed a questionnaire assessing safety, efficacy, tolerability, patient-satisfaction and self-reported adherence to TIS at baseline and during 12 months of TIP therapy. FEV1% predicted and exacerbation rate were recorded at each visit. RESULTS: There was a significant improvement in adherence scores, with a significant decrease in the number of intravenous antibiotic courses received during 12 months of TIP compared with the preceding 12 months using TIS. 94% of patients who had previously used TIS preferred TIP therapy over TIS. CONCLUSIONS: Inhaled powder tobramycin in CF is associated with improved adherence, tolerability and decreased exacerbation rates compared to nebulised treatment in real-life practice.
Authors: Maria T Nelson; Daniel J Wolter; Alexander Eng; Eli J Weiss; Anh T Vo; Mitchell J Brittnacher; Hillary S Hayden; Sumedha Ravishankar; Gilbert Bautista; Anina Ratjen; Marcella Blackledge; Sharon McNamara; Laura Nay; Cheryl Majors; Samuel I Miller; Elhanan Borenstein; Richard H Simon; John J LiPuma; Luke R Hoffman Journal: Thorax Date: 2020-07-06 Impact factor: 9.139
Authors: Jonathan Greenberg; Jacqueline B Palmer; Wing W Chan; Catherine E Correia; Diane Whalley; Paul Shannon; Gregory S Sawicki Journal: Patient Prefer Adherence Date: 2016-10-26 Impact factor: 2.711