Literature DB >> 2481509

Increased cytotoxicity of nanoparticle-carried Adriamycin in vitro and potentiation by verapamil and amiodarone.

C Kubiak1, P Couvreur, L Manil, B Clausse.   

Abstract

The cytotoxicities of free cyanoacrylic nanoparticles, free Adriamycin, Adriamycin-loaded nanoparticles and a mixture of Adriamycin and nanoparticles are compared in cancer cell cultures. Increased cytotoxicity was observed in the sensitive (DC3F) subline when Adriamycin was in particulate form rather than free. In the derived pleiotropic resistant subline (DC3F AD/AZA), sensitivity to Adriamycin was completely restored with the conjugate. Addition of verapamil or amiodarone allowed an enhancement of efficiency of tenfold for free Adriamycin and between two- and fourfold for its conjugate form. Vectorization by nanoparticles and pharmacological modulation of cell membrane can act in synergy in synergy to overcome the resistance to Adriamycin in vitro.

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Year:  1989        PMID： 2481509     DOI： 10.1016/0142-9612(89)90062-8

Source DB:  PubMed          Journal:  Biomaterials        ISSN： 0142-9612            Impact factor:   12.479


  5 in total

1.  Circumventing tumor resistance to chemotherapy by nanotechnology.

Authors:  Xing-Jie Liang; Chunying Chen; Yuliang Zhao; Paul C Wang
Journal:  Methods Mol Biol       Date:  2010

2.  Phase I clinical trial and pharmacokinetic evaluation of doxorubicin carried by polyisohexylcyanoacrylate nanoparticles.

Authors:  J Kattan; J P Droz; P Couvreur; J P Marino; A Boutan-Laroze; P Rougier; P Brault; H Vranckx; J M Grognet; X Morge
Journal:  Invest New Drugs       Date:  1992-08       Impact factor: 3.850

3.  Functional protein delivery into neurons using polymeric nanoparticles.

Authors:  Linda Hasadsri; Jörg Kreuter; Hiroaki Hattori; Tadao Iwasaki; Julia M George
Journal:  J Biol Chem       Date:  2009-01-07       Impact factor: 5.157

4.  Comparison of the liver subcellular distribution of free daunomycin and that bound to galactosamine targeted N-(2-hydroxypropyl)methacrylamide copolymers, following intravenous administration in the rat.

Authors:  S R Wedge; R Duncan; P Kopeckova
Journal:  Br J Cancer       Date:  1991-04       Impact factor: 7.640

Review 5.  When neurons encounter nanoobjects: spotlight on calcium signalling.

Authors:  Davide Lovisolo; Alessandra Gilardino; Federico Alessandro Ruffinatti
Journal:  Int J Environ Res Public Health       Date:  2014-09-16       Impact factor: 3.390
  5 in total

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