Mehmet Salih Aydin1, Ahmet Caliskan2, Aydemir Kocarslan3, Sezen Kocarslan4, Ali Yildiz5, Samil Günay6, Emin Savik7, Abdussemet Hazar3, Funda Yalcin8. 1. Harran University Faculty of Medicine, Department of Cardiovascular Surgery, Sanliurfa, Turkey. Electronic address: drmsalihaydin@harran.edu.tr. 2. Dicle University Faculty of Medicine, Department of Cardiovascular Surgery, Diyarbakır, Turkey. 3. Harran University Faculty of Medicine, Department of Cardiovascular Surgery, Sanliurfa, Turkey. 4. Harran University Medical Faculty, Department of Pathology, Sanliurfa, Turkey. 5. Harran University Medical Faculty, Department of Cardiology, Sanliurfa, Turkey. 6. Harran University Medical Faculty, Department of Thoracic Surgery, Sanliurfa, Turkey. 7. Harran University Medical Faculty, Department of Biochemistry, Sanliurfa, Turkey. 8. Harran University Medical Faculty, Department of Biochemistry, Sanliurfa, Turkey; Harran University Medical Faculty, Department of Chest Disease, Sanliurfa, Turkey.
Abstract
BACKGROUND: Previous studies have demonstrated that curcumin (CUR) has protective effects against ischemia reperfusion injury to various organs. We aimed to determine whether CUR has favorable effects on tissues and oxidative stress in abdominal aorta ischemia-reperfusion injury. MATERIALS AND METHODS: Thirty rats were divided into three groups as sham, control and treatment (CUR) group. Control and CUR groups underwent abdominal aorta ischemia for 60 min followed by a 120 min period of reperfusion. In the CUR group, CUR was given 5 min before reperfusion at a dose of 200 mg/kg via an intraperitoneal route. Total antioxidant capacity (TAC), total oxidative status (TOS), and oxidative stress index (OSI) in blood serum were measured, and lung, renal and heart tissue histopathology were evaluated with light microscopy. RESULTS: TOS and OSI activity in blood samples were statistically decreased in sham and CUR groups compared to the control group (p < 0.001 for TOS and OSI). Renal, lung, heart injury scores of sham and CUR groups were statistically decreased compared to control group (p < 0.001 for all comparisons). Histopathological examination revealed less severe lesions in CUR group than in the control group. CONCLUSION: CUR administered intraperitoneally was effective in reducing oxidative stress and histopathologic injury in an acute abdominal aorta I/R rat model.
BACKGROUND: Previous studies have demonstrated that curcumin (CUR) has protective effects against ischemia reperfusion injury to various organs. We aimed to determine whether CUR has favorable effects on tissues and oxidative stress in abdominal aorta ischemia-reperfusion injury. MATERIALS AND METHODS: Thirty rats were divided into three groups as sham, control and treatment (CUR) group. Control and CUR groups underwent abdominal aorta ischemia for 60 min followed by a 120 min period of reperfusion. In the CUR group, CUR was given 5 min before reperfusion at a dose of 200 mg/kg via an intraperitoneal route. Total antioxidant capacity (TAC), total oxidative status (TOS), and oxidative stress index (OSI) in blood serum were measured, and lung, renal and heart tissue histopathology were evaluated with light microscopy. RESULTS:TOS and OSI activity in blood samples were statistically decreased in sham and CUR groups compared to the control group (p < 0.001 for TOS and OSI). Renal, lung, heart injury scores of sham and CUR groups were statistically decreased compared to control group (p < 0.001 for all comparisons). Histopathological examination revealed less severe lesions in CUR group than in the control group. CONCLUSION: CUR administered intraperitoneally was effective in reducing oxidative stress and histopathologic injury in an acute abdominal aorta I/R rat model.
Authors: Orhan Tezcan; Oguz Karahan; Mustafa Alan; Cenap Ekinci; Celal Yavuz; Sinan Demirtas; Aysun Ekinci; Ahmet Caliskan Journal: Acta Cardiol Sin Date: 2017-03 Impact factor: 2.672
Authors: Amit X Garg; P J Devereaux; Andrew Hill; Manish Sood; Bharat Aggarwal; Luc Dubois; Swapnil Hiremath; Randolph Guzman; Vikram Iyer; Matthew James; Eric McArthur; Louise Moist; George Ouellet; Chirag R Parikh; Virginia Schumann; Sumit Sharan; Heather Thiessen-Philbrook; Sheldon Tobe; Ron Wald; Michael Walsh; Matthew Weir; Neesh Pannu Journal: CMAJ Date: 2018-10-29 Impact factor: 8.262
Authors: Aydemir Koçarslan; Sezen Koçarslan; Mehmet Salih Aydin; Şamil Gunay; Mahmut Alp Karahan; Abdullah Taşkın; Murat Üstunel; Nurten Aksoy Journal: Braz J Cardiovasc Surg Date: 2016 Nov-Dec