AIM: Gender has been considered as one of the possible factors mediating phenotypic expression of obsessive-compulsive disorder (OCD). We examined gender differences in a large sample of subjects with OCD from India with respect to socio-demographic parameters, symptom characteristics, and comorbidity patterns. METHODS: Consecutive patients (n=545) who consulted a specialty OCD clinic over 5 years at a large psychiatric hospital in India were evaluated. RESULTS: Men (n=332) compared to women (n=213) with OCD had an earlier onset (p<0.001), higher frequency of sexual (p<0.001) and religious obsessions (p=0.001) pathological doubts (p<0.001) and checking (p<0.001) and repeating compulsions (p<0.001), and a greater tendency to have comorbid social phobia (p=0.006). Women compared to men were more likely to be married, had a higher frequency of fear of contamination (p=0.017), comorbid depression (p=0.014) and greater suicidal risk (p=0.003). CONCLUSIONS: Our study provides further evidence for gender related differences in clinical features of obsessive-compulsive disorder. Our findings are only partly comparable with results from studies across the world possibly due to various biological and cultural factors mediating the phenotypic expression of OCD across the genders. There is a need to examine the biological basis for these gender differences.
AIM: Gender has been considered as one of the possible factors mediating phenotypic expression of obsessive-compulsive disorder (OCD). We examined gender differences in a large sample of subjects with OCD from India with respect to socio-demographic parameters, symptom characteristics, and comorbidity patterns. METHODS: Consecutive patients (n=545) who consulted a specialty OCD clinic over 5 years at a large psychiatric hospital in India were evaluated. RESULTS:Men (n=332) compared to women (n=213) with OCD had an earlier onset (p<0.001), higher frequency of sexual (p<0.001) and religious obsessions (p=0.001) pathological doubts (p<0.001) and checking (p<0.001) and repeating compulsions (p<0.001), and a greater tendency to have comorbid social phobia (p=0.006). Women compared to men were more likely to be married, had a higher frequency of fear of contamination (p=0.017), comorbid depression (p=0.014) and greater suicidal risk (p=0.003). CONCLUSIONS: Our study provides further evidence for gender related differences in clinical features of obsessive-compulsive disorder. Our findings are only partly comparable with results from studies across the world possibly due to various biological and cultural factors mediating the phenotypic expression of OCD across the genders. There is a need to examine the biological basis for these gender differences.
Authors: D R M A Højgaard; E L Mortensen; T Ivarsson; K Hybel; G Skarphedinsson; J B Nissen; R Valderhaug; K Dahl; B Weidle; N C Torp; M Grados; A B Lewin; K H Melin; E A Storch; L H Wolters; T K Murphy; E J S Sonuga-Barke; P H Thomsen Journal: Eur Child Adolesc Psychiatry Date: 2016-07-07 Impact factor: 4.785
Authors: Cristian Sebastian Melia; Virginia Soria; Neus Salvat-Pujol; Ángel Cabezas; Roser Nadal; Mikel Urretavizcaya; Alfonso Gutiérrez-Zotes; José Antonio Monreal; José Manuel Crespo; Pino Alonso; Elisabet Vilella; Diego Palao; José Manuel Menchón; Javier Labad Journal: Biol Sex Differ Date: 2019-12-02 Impact factor: 5.027