Literature DB >> 24812603

Dissecting the pleiotropic actions of HBx mutants against hypoxia in hepatocellular carcinoma.

Ying-Ying Lee1, Myth T S Mok1, Alfred Sze-Lok Cheng1.   

Abstract

Error-prone integration of the hepatitis B virus X protein (HBx) into the hepatocellular genome generates a multitude of mutants exerting diverse effects on the development and progression of hepatocellular carcinoma (HCC). A recent study by Lai and colleagues revealed the disparate regulatory activity of clinically-predominant HBx mutants towards hypoxia-inducible factor-1α (HIF-1α), a central regulator of tumor angiogenesis, proliferation, metastasis and differentiation. These findings have shed insight into specific viral contribution of hypoxic response during hepatocarcinogenesis.

Entities:  

Keywords:  Hepatitis B virus X protein mutant (HBx mutant); hepatocellular carcinoma (HCC); hypoxia-inducible factor-1α (HIF-1α)

Year:  2014        PMID： 24812603      PMCID： PMC3999418          DOI： 10.3978/j.issn.2304-3881.2014.02.07

Source DB:  PubMed          Journal:  Hepatobiliary Surg Nutr        ISSN： 2304-3881            Impact factor:   7.293


  20 in total

1.  RNA interference targeting HBx suppresses tumor growth and enhances cisplatin chemosensitivity in human hepatocellular carcinoma.

Authors:  Alfred S L Cheng; Nathalie Wong; Ada M Y Tse; Kathy Y Y Chan; Kai K Chan; Joseph J Y Sung; Henry L Y Chan
Journal:  Cancer Lett       Date:  2007-02-12       Impact factor: 8.679

2.  Cell cycle-related kinase mediates viral-host signalling to promote hepatitis B virus-associated hepatocarcinogenesis.

Authors:  Zhuo Yu; Yue-Qiu Gao; Hai Feng; Ying-Ying Lee; May S Li; Yuan Tian; Minnie Y Y Go; Dae-Yeul Yu; Yue-Sun Cheung; Paul B S Lai; Jun Yu; Vincent W S Wong; Joseph J Y Sung; Henry L Y Chan; Alfred S L Cheng
Journal:  Gut       Date:  2014-01-17       Impact factor: 23.059

Review 3.  Mechanisms of HBV-related hepatocarcinogenesis.

Authors:  Christine Neuveut; Yu Wei; Marie Annick Buendia
Journal:  J Hepatol       Date:  2010-01-07       Impact factor: 25.083

4.  The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-1alpha.

Authors:  Young-Gun Yoo; Sayeon Cho; Sun Park; Mi-Ock Lee
Journal:  FEBS Lett       Date:  2004-11-05       Impact factor: 4.124

5.  A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function.

Authors:  V Kumar; N Jayasuryan; R Kumar
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-28       Impact factor: 11.205

6.  COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosis.

Authors:  Alfred S L Cheng; Jun Yu; Paul B S Lai; Henry L Y Chan; Joseph J Y Sung
Journal:  Biochem Biophys Res Commun       Date:  2008-07-02       Impact factor: 3.575

7.  Posthepatectomy HBV reactivation in hepatitis B-related hepatocellular carcinoma influences postoperative survival in patients with preoperative low HBV-DNA levels.

Authors:  Gang Huang; Eric C H Lai; Wan Yee Lau; Wei-ping Zhou; Feng Shen; Ze-ya Pan; Si-yuan Fu; Meng-chao Wu
Journal:  Ann Surg       Date:  2013-03       Impact factor: 12.969

8.  Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells.

Authors:  Y-G Yoo; T-Y Na; H-W Seo; J K Seong; C K Park; Y K Shin; M-O Lee
Journal:  Oncogene       Date:  2008-02-11       Impact factor: 9.867

9.  Carboxyl-terminal truncated HBx regulates a distinct microRNA transcription program in hepatocellular carcinoma development.

Authors:  Wing-Kit Yip; Alfred Sze-Lok Cheng; Ranxu Zhu; Raymond Wai-Ming Lung; Daisy Pui-Fong Tsang; Suki Shuk-Kei Lau; Yangchao Chen; Jonathan Gabriel Sung; Paul Bo-San Lai; Enders Kai-On Ng; Jun Yu; Nathalie Wong; Ka-Fai To; Vincent Wai-Sun Wong; Joseph Jao-Yiu Sung; Henry Lik-Yuen Chan
Journal:  PLoS One       Date:  2011-08-04       Impact factor: 3.240

10.  HBx mutants differentially affect the activation of hypoxia-inducible factor-1α in hepatocellular carcinoma.

Authors:  L-P Liu; B-G Hu; C Ye; R L K Ho; G G Chen; P B S Lai
Journal:  Br J Cancer       Date:  2013-12-17       Impact factor: 7.640
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  1 in total

1.  Somatic mutation profiling of liver and biliary cancer by targeted next generation sequencing.

Authors:  Bo-Lun Zhang; Xu Ji; Ling-Xiang Yu; Yuan Gao; Chao-Hui Xiao; Jia Liu; De-Xi Zhao; Yi Le; Guang-Hao Diao; Jia-Yi Sun; Gao-Hua Li; Guang-Lin Lei; Peng Yu; Rui-Lan Wang; Jian-Zhong Wu; Peng-Hui Yang; Jin Yan; Jing-Yu Li; Jia-Jia Xu; Shao-Geng Zhang; Hu Tian
Journal:  Oncol Lett       Date:  2018-08-29       Impact factor: 2.967
  1 in total

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