Daeun Ryu1, SeongBeom Cho2, Hun Kim1, Sanghyuk Lee2, Wankyu Kim2. 1. Ewha Research Center for Systems Biology (ERCSB), Ewha Womans University, Seoul 120-750, Division of Biomedical Informatics, National Institute of Health, Korea Center for Disease Control, Cheongwon 363-951 and Ewha Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Republic of Korea. 2. Ewha Research Center for Systems Biology (ERCSB), Ewha Womans University, Seoul 120-750, Division of Biomedical Informatics, National Institute of Health, Korea Center for Disease Control, Cheongwon 363-951 and Ewha Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Republic of Korea Ewha Research Center for Systems Biology (ERCSB), Ewha Womans University, Seoul 120-750, Division of Biomedical Informatics, National Institute of Health, Korea Center for Disease Control, Cheongwon 363-951 and Ewha Global Top5 Research Program, Ewha Womans University, Seoul 120-750, Republic of Korea.
Abstract
UNLABELLED: GEPdb integrates both genome-wide association studies and expression quantitative trait loci information, the two primary sources of genome-wide mapping for genotype-phenotype and genotype-expression associations together with phenotype-associated gene lists. The GEPdb provides simultaneous interpretation of both genetic risks and potential gene regulatory pathways toward phenotypic outcome by establishing the ternary relationship of genotype-expression-phenotype (GEP). The analytic scope is further extended by linkage disequilibrium from five different populations of the international HapMap Project. AVAILABILITY AND IMPLEMENTATION: http://ercsbweb.ewha.ac.kr/gepdb.
UNLABELLED: GEPdb integrates both genome-wide association studies and expression quantitative trait loci information, the two primary sources of genome-wide mapping for genotype-phenotype and genotype-expression associations together with phenotype-associated gene lists. The GEPdb provides simultaneous interpretation of both genetic risks and potential gene regulatory pathways toward phenotypic outcome by establishing the ternary relationship of genotype-expression-phenotype (GEP). The analytic scope is further extended by linkage disequilibrium from five different populations of the international HapMap Project. AVAILABILITY AND IMPLEMENTATION: http://ercsbweb.ewha.ac.kr/gepdb.
Authors: Peter J Castaldi; Michael H Cho; Xiaobo Zhou; Weiliang Qiu; Michael Mcgeachie; Bartolome Celli; Per Bakke; Amund Gulsvik; David A Lomas; James D Crapo; Terri H Beaty; Stephen Rennard; Benjamin Harshfield; Christoph Lange; Dave Singh; Ruth Tal-Singer; John H Riley; John Quackenbush; Benjamin A Raby; Vincent J Carey; Edwin K Silverman; Craig P Hersh Journal: Hum Mol Genet Date: 2014-10-14 Impact factor: 6.150