Literature DB >> 24811313

Polymers fight HIV: potent (pro)drugs identified through parallel automated synthesis.

Kaja Zuwala1, Anton A A Smith, Almar Postma, Carlos Guerrero-Sanchez, Pau Ruiz-Sanchis, Jesper Melchjorsen, Martin Tolstrup, Alexander N Zelikin.   

Abstract

Macromolecular (pro)drugs interfere with the proliferation of HIV through both inhibition of viral cell entry and via intracellular delivery of antiviral drugs. Lead polymer conjugates exhibit longevity of action exceeding that of parent nucleoside analogue drug and are active in primary T cell over at least 72 h.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  HIV; drug delivery; polymers; prodrugs

Mesh：

Substances：

Year:  2014        PMID： 24811313     DOI： 10.1002/adhm.201400148

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   9.933


  4 in total

1.  A prodrug micellar carrier assembled from polymers with pendant farnesyl thiosalicylic acid moieties for improved delivery of paclitaxel.

Authors:  Jingjing Sun; Yichao Chen; Ke Li; Yixian Huang; Xiaofeng Fu; Xiaolan Zhang; Wenchen Zhao; Yuan Wei; Liang Xu; Peijun Zhang; Raman Venkataramanan; Song Li
Journal:  Acta Biomater       Date:  2016-07-12       Impact factor: 8.947

2.  Macromolecular prodrugs of ribavirin: towards a treatment for co-infection with HIV and HCV.

Authors:  Anton A A Smith; Kaja Zuwala; Mille B L Kryger; Benjamin M Wohl; Carlos Guerrero-Sanchez; Martin Tolstrup; Almar Postma; Alexander N Zelikin
Journal:  Chem Sci       Date:  2014-09-16       Impact factor: 9.825

Review 3.  Advanced Prodrug Strategies in Nucleoside and Non-Nucleoside Antiviral Agents: A Review of the Recent Five Years.

Authors:  Hanadi Sinokrot; Tasneem Smerat; Anas Najjar; Rafik Karaman
Journal:  Molecules       Date:  2017-10-16       Impact factor: 4.411

Review 4.  The evolution of nucleosidic analogues: self-assembly of prodrugs into nanoparticles for cancer drug delivery.

Authors:  Milad Baroud; Elise Lepeltier; Sylvain Thepot; Yolla El-Makhour; Olivier Duval
Journal:  Nanoscale Adv       Date:  2021-02-22
  4 in total

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