Q Y Shi1, J B Zhang2, Y Q Mi3, Y Song4, J Ma5, Y L Zhang6. 1. Tianjin Second People's Hospital, School of Graduate, Tianjin Medical University, Tianjin, China. 2. Tianjin Teda International Cardiovascular Disease Hospital, Clinical College of Cardiovascular, Tianjin Medical University, Tianjin, China. 3. Depanment of Chinese Integrative Medicine, Tianjin Second People's Hospital, Tianjin Medical University, Tianjin, China. 4. Coronary Care Unit, Tianjin Teda International Cardiovascular Disease Hospital, Clinical College of Cardiovascular, Tianjin Medical University, Tianjin, China. 5. Department of Health Statistics, College of Public Health, Tianjin Medical University, Tianjin, China. 6. 1] Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, School of Public Health, Peking University Health Science Center, Beijing, China [2] Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Abstract
OBJECTIVE: To systematically review and meta-analyze the relation between maternal fever in the first trimester and congenital heart defect (CHD) in offspring. STUDY DESIGN: We searched PubMed (1977-2012), Embase (1974-2012) and the Cochrane Library (2012) databases to identify relevant articles. Random effects model were performed, with the conduction of subgroup analysis. RESULT: Meta-analysis yielded a pooled odds ratio of 1.53 (95% confidence interval=1.36 to 1.73) for the magnitude of the relation between maternal fever in the first trimester and CHD in offspring. As to subgroup analysis, it is associated with ventricular septal defects (VSDs) and right obstructive defects. CONCLUSION: Our analysis suggests that maternal fever in the first trimester is the risk factor of congenital heart diseases in offspring. Through the subgroup analysis, we find that exposure to maternal fever is the risk factor of VSD and right obstructive defects.
OBJECTIVE: To systematically review and meta-analyze the relation between maternal fever in the first trimester and congenital heart defect (CHD) in offspring. STUDY DESIGN: We searched PubMed (1977-2012), Embase (1974-2012) and the Cochrane Library (2012) databases to identify relevant articles. Random effects model were performed, with the conduction of subgroup analysis. RESULT: Meta-analysis yielded a pooled odds ratio of 1.53 (95% confidence interval=1.36 to 1.73) for the magnitude of the relation between maternal fever in the first trimester and CHD in offspring. As to subgroup analysis, it is associated with ventricular septal defects (VSDs) and right obstructive defects. CONCLUSION: Our analysis suggests that maternal fever in the first trimester is the risk factor of congenital heart diseases in offspring. Through the subgroup analysis, we find that exposure to maternal fever is the risk factor of VSD and right obstructive defects.
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