Literature DB >> 24810598

Palladium-catalyzed one-pot synthesis of quinazolinones via tert-butyl isocyanide insertion.

Xiao Jiang1, Ting Tang, Jin-Mei Wang, Zhong Chen, Yong-Ming Zhu, Shun-Jun Ji.   

Abstract

A novel palladium-catalyzed three-component reaction for the synthesis of quinazolin-4(3H)-ones from readily available 2-aminobenzamides and aryl halides via a palladium-catalyzed isocyanide insertion/cyclization sequence has been developed. This methodology efficiently constructs quinazolin-4(3H)-ones in moderate to excellent yields with the advantages of operational simplicity.

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Year:  2014        PMID： 24810598     DOI： 10.1021/jo500636y

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  4 in total

1.  "On-Water" Synthesis of Quinazolinones and Dihydroquinazolinones Starting from o-Bromobenzonitrile.

Authors:  Zibin Liu; Li-Yan Zeng; Chao Li; Fubiao Yang; Fensheng Qiu; Shuwen Liu; Baomin Xi
Journal:  Molecules       Date:  2018-09-12       Impact factor: 4.411

2.  Quinazolin-4(3H)-ones and 5,6-Dihydropyrimidin-4(3H)-ones from β-Aminoamides and Orthoesters.

Authors:  Joshua T Gavin; Joel K Annor-Gyamfi; Richard A Bunce
Journal:  Molecules       Date:  2018-11-09       Impact factor: 4.411

3.  β-Cyclodextrin: a supramolecular catalyst for metal-free approach towards the synthesis of 2-amino-4,6-diphenylnicotinonitriles and 2,3-dihydroquinazolin-4(1H)-one.

Authors:  Bijeta Mitra; Gyan Chandra Pariyar; Pranab Ghosh
Journal:  RSC Adv       Date:  2021-01-05       Impact factor: 3.361

4.  ortho-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3H)-ones: a convergent synthetic route to bouchardatine and sildenafil.

Authors:  Kyeongha Kim; Hun Young Kim; Kyungsoo Oh
Journal:  RSC Adv       Date:  2020-08-21       Impact factor: 4.036
  4 in total

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