Literature DB >> 24810245

Tumor acquisition for biomarker research in lung cancer.

Marvaretta Stevenson1, Jared Christensen, Debra Shoemaker, Traci Foster, William T Barry, Betty C Tong, Momen Wahidi, Scott Shofer, Michael Datto, Geoffrey Ginsburg, Jeffrey Crawford, Thomas D'Amico, Neal Ready.   

Abstract

The biopsy collection data from two lung cancer trials that required fresh tumor samples be obtained for microarray analysis were reviewed. In the trial for advanced disease, microarray data were obtained on 50 patient samples, giving an overall success rate of 60.2%. The majority of the specimens were obtained through CT-guided lung biopsies (N = 30). In the trial for early-stage patients, 28 tissue specimens were collected from excess tumor after surgical resection with a success rate of 85.7%. This tissue procurement program documents the feasibility in obtaining fresh tumor specimens prospectively that could be used for molecular testing.

Entities:  

Keywords:  Bioinformatics; Gene profiling; Lung cancer

Mesh:

Substances:

Year:  2014        PMID: 24810245      PMCID: PMC4336177          DOI: 10.3109/07357907.2014.911880

Source DB:  PubMed          Journal:  Cancer Invest        ISSN: 0735-7907            Impact factor:   2.176


  34 in total

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Review 4.  Metastatic tumours of the adrenal glands: a 30-year experience in a teaching hospital.

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5.  Effects of tissue handling on RNA integrity and microarray measurements from resected breast cancers.

Authors:  Christos Hatzis; Hongxia Sun; Hui Yao; Rebekah E Hubbard; Funda Meric-Bernstam; Gildy V Babiera; Yun Wu; Lajos Pusztai; W Fraser Symmans
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6.  PARAMOUNT: Final overall survival results of the phase III study of maintenance pemetrexed versus placebo immediately after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer.

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7.  A multicentre phase II gene expression profiling study of putative relationships between tumour biomarkers and clinical response with erlotinib in non-small-cell lung cancer.

Authors:  E-H Tan; R Ramlau; A Pluzanska; H-P Kuo; M Reck; J Milanowski; J S-K Au; E Felip; P-C Yang; D Damyanov; S Orlov; M Akimov; P Delmar; L Essioux; C Hillenbach; B Klughammer; P McLoughlin; J Baselga
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8.  Feasibility of image-guided transthoracic core-needle biopsy in the BATTLE lung trial.

Authors:  Alda L Tam; Edward S Kim; J Jack Lee; Joe E Ensor; Marshall E Hicks; Ximing Tang; George R Blumenschein; Christine M Alden; Jeremy J Erasmus; Anne Tsao; Scott M Lippman; Waun K Hong; Ignacio I Wistuba; Sanjay Gupta
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9.  Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer.

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10.  Factors associated with pneumothorax and pneumothorax requiring treatment after percutaneous lung biopsy in 443 consecutive patients.

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2.  Comprehensive serial biobanking in advanced NSCLC: feasibility, challenges and perspectives.

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  2 in total

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