INTRODUCTION: Distal symmetric polyneuropathy (DSP) is common in HIV and is associated with autonomic impairment. However tools to measure HIV-DSP do not include autonomic indices. We sought to optimize the Total Neuropathy Score (TNS) and the Composite Autonomic Severity Score (CASS) for use in HIV. METHODS: HIV-infected adults (n = 102) underwent neurologic examination, quantitative sensory testing (QST), nerve conduction studies, and autonomic testing. Modifications of the TNS and CASS were assessed for validity based on correlation with the original measure and internal consistency. RESULTS: The TNS version commonly used in HIV-DSP is valid, but it is improved by elimination of QST and addition of autonomic indices. A modified version of the CASS (M-CASS) which was designed for sensitivity to milder impairment was also valid. CONCLUSIONS: A modified TNS that excludes QST and includes autonomic indices is optimal for HIV-DSP. The M-CASS is a valid measure of autonomic impairment in HIV.
INTRODUCTION: Distal symmetric polyneuropathy (DSP) is common in HIV and is associated with autonomic impairment. However tools to measure HIV-DSP do not include autonomic indices. We sought to optimize the Total Neuropathy Score (TNS) and the Composite Autonomic Severity Score (CASS) for use in HIV. METHODS:HIV-infected adults (n = 102) underwent neurologic examination, quantitative sensory testing (QST), nerve conduction studies, and autonomic testing. Modifications of the TNS and CASS were assessed for validity based on correlation with the original measure and internal consistency. RESULTS: The TNS version commonly used in HIV-DSP is valid, but it is improved by elimination of QST and addition of autonomic indices. A modified version of the CASS (M-CASS) which was designed for sensitivity to milder impairment was also valid. CONCLUSIONS: A modified TNS that excludes QST and includes autonomic indices is optimal for HIV-DSP. The M-CASS is a valid measure of autonomic impairment in HIV.
Authors: Ronald J Ellis; Debralee Rosario; David B Clifford; Justin C McArthur; David Simpson; Terry Alexander; Benjamin B Gelman; Florin Vaida; Ann Collier; Christina M Marra; Beau Ances; J Hampton Atkinson; Robert H Dworkin; Susan Morgello; Igor Grant Journal: Arch Neurol Date: 2010-05
Authors: L Zilliox; A C Peltier; P A Wren; A Anderson; A G Smith; J R Singleton; E L Feldman; N B Alexander; J W Russell Journal: Neurology Date: 2011-03-22 Impact factor: 9.910
Authors: Christine Schrezenmaier; Wolfgang Singer; Nicolette Muenter Swift; David Sletten; James Tanabe; Phillip A Low Journal: Arch Neurol Date: 2007-03
Authors: Jessica Robinson-Papp; Benjamin B Gelman; Igor Grant; Elyse Singer; Gary Gensler; Susan Morgello Journal: Muscle Nerve Date: 2012-04 Impact factor: 3.217
Authors: J Robinson-Papp; S Morgello; F Vaida; C Fitzsimons; D M Simpson; K J Elliott; M Al-Lozi; B B Gelman; D Clifford; C M Marra; J A McCutchan; J H Atkinson; R H Dworkin; I Grant; R Ellis Journal: Pain Date: 2010-09-20 Impact factor: 6.961
Authors: Jessica Robinson-Papp; Alexandra Nmashie; Elizabeth Pedowitz; Mary Catherine George; Sandeep Sharma; Jacinta Murray; Emma K T Benn; Steven A Lawrence; Josef Machac; Sherif Heiba; Seunghee Kim-Schulze; Allison Navis; Bani Chander Roland; Susan Morgello Journal: J Neurovirol Date: 2019-05-16 Impact factor: 2.643
Authors: Mary Catherine George; Arada Wongmek; Michelle Kaku; Alexandra Nmashie; Jessica Robinson-Papp Journal: Behav Med Date: 2015-12-11 Impact factor: 3.104
Authors: Jessica Robinson-Papp; Varuna Astha; Alexandra Nmashie; Sandeep K Sharma; Seunghee Kim-Schulze; Jacinta Murray; Mary Catherine George; Susan Morgello; Bridget R Mueller; Steven A Lawrence; Emma K T Benn Journal: Brain Behav Immun Health Date: 2020-08-03