Literature DB >> 24809833

Rho GTPases, oxidation, and cell redox control.

G Aaron Hobbs1, Bingying Zhou2, Adrienne D Cox3, Sharon L Campbell4.   

Abstract

While numerous studies support regulation of Ras GTPases by reactive oxygen and nitrogen species, the Rho subfamily has received considerably less attention. Over the last few years, increasing evidence is emerging that supports the redox sensitivity of Rho GTPases. Moreover, as Rho GTPases regulate the cellular redox state by controlling enzymes that generate and convert reactive oxygen and nitrogen species, redox feedback loops likely exist. Here, we provide an overview of cellular oxidants, Rho GTPases, and their inter-dependence.

Entities:  

Keywords:  2-electron oxidants; Ras GTPases; cysteine oxidation; free radicals; post-translational modifications; reactive nitrogen species; reactive oxygen species

Mesh：

Substances：

Year:  2014        PMID： 24809833      PMCID： PMC4114927          DOI： 10.4161/sgtp.28579

Source DB:  PubMed          Journal:  Small GTPases        ISSN： 2154-1248


  139 in total

1.  Ras and RhoA suppress whereas RhoB enhances cytokine-induced transcription of nitric oxide synthase-2 in human normal liver AKN-1 cells and lung cancer A-549 cells.

Authors:  F L Delarue; B S Taylor; S M Sebti
Journal:  Oncogene       Date:  2001-10-04       Impact factor: 9.867

2.  Mechanism of redox-mediated guanine nucleotide exchange on redox-active Rho GTPases.

Authors:  Jongyun Heo; Sharon L Campbell
Journal:  J Biol Chem       Date:  2005-06-30       Impact factor: 5.157

3.  Rapid Stimulation of an Oxidative Burst during Elicitation of Cultured Plant Cells : Role in Defense and Signal Transduction.

Authors:  I Apostol; P F Heinstein; P S Low
Journal:  Plant Physiol       Date:  1989-05       Impact factor: 8.340

Review 4.  Free radical biology and medicine: it's a gas, man!

Authors:  William A Pryor; Kendall N Houk; Christopher S Foote; Jon M Fukuto; Louis J Ignarro; Giuseppe L Squadrito; Kelvin J A Davies
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2006-04-20       Impact factor: 3.619

5.  Tumorigenic 3T3 cells maintain an alkaline intracellular pH under physiological conditions.

Authors:  R J Gillies; R Martinez-Zaguilan; G M Martinez; R Serrano; R Perona
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

Review 6.  Oxidative stress, insulin signaling, and diabetes.

Authors:  Justin L Rains; Sushil K Jain
Journal:  Free Radic Biol Med       Date:  2010-12-13       Impact factor: 7.376

Review 7.  Nitric oxide and thiol groups.

Authors:  B Gaston
Journal:  Biochim Biophys Acta       Date:  1999-05-05

8.  Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.

Authors:  Atsuo T Sasaki; Arkaitz Carracedo; Jason W Locasale; Dimitrios Anastasiou; Koh Takeuchi; Emily Rose Kahoud; Sasson Haviv; John M Asara; Pier Paolo Pandolfi; Lewis C Cantley
Journal:  Sci Signal       Date:  2011-03-08       Impact factor: 8.192

9.  H2O2 activates G protein, α 12 to disrupt the junctional complex and enhance ischemia reperfusion injury.

Authors:  Wanfeng Yu; Sarah Beaudry; Hideyuki Negoro; Ilene Boucher; Mei Tran; Tianqing Kong; Bradley M Denker
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-09       Impact factor: 11.205

10.  Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motif.

Authors:  Amir Aghajanian; Erika S Wittchen; Sharon L Campbell; Keith Burridge
Journal:  PLoS One       Date:  2009-11-26       Impact factor: 3.240
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  28 in total

1.  Rho GTPases at the crossroad of signaling networks in mammals.

Authors:  Jean Claude Hervé; Nicolas Bourmeyster
Journal:  Small GTPases       Date:  2015-06-25

2.  Rho and Reactive Oxygen Species at Crossroads of Endothelial Permeability and Inflammation.

Authors:  Pratap Karki; Konstantin G Birukov
Journal:  Antioxid Redox Signal       Date:  2019-06-28       Impact factor: 8.401

3.  Unraveling a model of TCL/RhoJ allosterism using TC10 reverse chimeras.

Authors:  Rebecca R Florke; Grace T Young; Michael J Hamann
Journal:  Small GTPases       Date:  2017-10-03

Review 4.  Oxidative stress in phenylketonuria-evidence from human studies and animal models, and possible implications for redox signaling.

Authors:  Vanessa Trindade Bortoluzzi; Carlos Severo Dutra Filho; Clovis Milton Duval Wannmacher
Journal:  Metab Brain Dis       Date:  2021-02-13       Impact factor: 3.584

5.  Oxidants in Physiological Processes.

Authors:  Ulla G Knaus
Journal:  Handb Exp Pharmacol       Date:  2021

6.  The Emerging Roles of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 2 in Skeletal Muscle Redox Signaling and Metabolism.

Authors:  Carlos Henríquez-Olguín; Susanna Boronat; Claudio Cabello-Verrugio; Enrique Jaimovich; Elena Hidalgo; Thomas E Jensen
Journal:  Antioxid Redox Signal       Date:  2019-11-01       Impact factor: 8.401

7.  Redox regulation of Rac1 by thiol oxidation.

Authors:  G Aaron Hobbs; Lauren E Mitchell; Megan E Arrington; Harsha P Gunawardena; Molly J DeCristo; Richard F Loeser; Xian Chen; Adrienne D Cox; Sharon L Campbell
Journal:  Free Radic Biol Med       Date:  2014-10-05       Impact factor: 7.376

Review 8.  Regulation of RhoA GTPase and novel target proteins for ROCK.

Authors:  Eun-Kyoung Choi; Jae-Gyu Kim; Hee-Jun Kim; Jung-Yoon Cho; Hwalrim Jeong; Yohan Park; Rokibul Islam; Cuong Kim Cap; Jae-Bong Park
Journal:  Small GTPases       Date:  2017-12-03

Review 9.  New insights into RhoA/Rho-kinase signaling: a key regulator of vascular contraction.

Authors:  Kenia Pedrosa Nunes; R Clinton Webb
Journal:  Small GTPases       Date:  2020-09-24

Review 10.  Raising the 'Good' Oxidants for Immune Protection.

Authors:  Alexia Dumas; Ulla G Knaus
Journal:  Front Immunol       Date:  2021-06-04       Impact factor: 7.561
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