Literature DB >> 2480895

Efficient tissue-specific expression of bovine alpha-lactalbumin in transgenic mice.

J L Vilotte1, S Soulier, M G Stinnakre, M Massoud, J C Mercier.   

Abstract

Transgenic mice carrying a 3.2-kb genomic fragment comprising the bovine alpha-lactalbumin gene transcription unit with 750 bp and 336 bp of 5' and 3' flanking regions, respectively, were generated. Tissue-specific expression of the transgene was observed in five out of the six lines analyzed at levels close to the endogenous gene in two of them.

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Year:  1989        PMID： 2480895     DOI： 10.1111/j.1432-1033.1989.tb15175.x

Source DB:  PubMed          Journal:  Eur J Biochem        ISSN： 0014-2956


  24 in total

1.  Efficient and specific ribozyme-mediated reduction of bovine alpha-lactalbumin expression in double transgenic mice.

Authors:  P J L'Huillier; S Soulier; M G Stinnakre; L Lepourry; S R Davis; J C Mercier; J L Vilotte
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

2.  Tissue-specific, high level expression of the rat whey acidic protein gene in transgenic mice.

Authors:  E M Bayna; J M Rosen
Journal:  Nucleic Acids Res       Date:  1990-05-25       Impact factor: 16.971

3.  Introduction of a proximal Stat5 site in the murine alpha-lactalbumin promoter induces prolactin dependency in vitro and improves expression frequency in vivo.

Authors:  S Soulier; L Lepourry; M G Stinnakre; B Langley; P J L'Huillier; J Paly; J Djiane; J C Mercier; J L Vilotte
Journal:  Transgenic Res       Date:  1999-02       Impact factor: 2.788

4.  Position-independent and copy-number-related expression of a goat bacterial artificial chromosome alpha-lactalbumin gene in transgenic mice.

Authors:  M G Stinnakre; S Soulier; L Schibler; L Lepourry; J C Mercier; J L Vilotte
Journal:  Biochem J       Date:  1999-04-01       Impact factor: 3.857

5.  Targeting expression to the mammary gland: intronic sequences can enhance the efficiency of gene expression in transgenic mice.

Authors:  C B Whitelaw; A L Archibald; S Harris; M McClenaghan; J P Simons; A J Clark
Journal:  Transgenic Res       Date:  1991-12       Impact factor: 2.788

6.  High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region.

Authors:  T C Dale; M J Krnacik; C Schmidhauser; C L Yang; M J Bissell; J M Rosen
Journal:  Mol Cell Biol       Date:  1992-03       Impact factor: 4.272

7.  High level production of human growth hormone in the milk of transgenic mice: the upstream region of the rabbit whey acidic protein (WAP) gene targets transgene expression to the mammary gland.

Authors:  E Devinoy; D Thépot; M G Stinnakre; M L Fontaine; H Grabowski; C Puissant; A Pavirani; L M Houdebine
Journal:  Transgenic Res       Date:  1994-03       Impact factor: 2.788

8.  Position-independent expression of the ovine beta-lactoglobulin gene in transgenic mice.

Authors:  C B Whitelaw; S Harris; M McClenaghan; J P Simons; A J Clark
Journal:  Biochem J       Date:  1992-08-15       Impact factor: 3.857

9.  Expression of human serum albumin in the milk of transgenic mice.

Authors:  M Shani; I Barash; M Nathan; G Ricca; G H Searfoss; I Dekel; A Faerman; D Givol; D R Hurwitz
Journal:  Transgenic Res       Date:  1992-09       Impact factor: 2.788

10.  Expression of the whey acidic protein in transgenic pigs impairs mammary development.

Authors:  A Shamay; V G Pursel; E Wilkinson; R J Wall; L Hennighausen
Journal:  Transgenic Res       Date:  1992-05       Impact factor: 2.788
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