Literature DB >> 24807743

Using non-human primates to benefit humans: research and organ transplantation.

David Shaw1, Wybo Dondorp, Guido de Wert.   

Abstract

Emerging biotechnology may soon allow the creation of genetically human organs inside animals, with non-human primates (henceforth simply "primates") and pigs being the best candidate species. This prospect raises the question of whether creating organs in primates in order to then transplant them into humans would be more (or less) acceptable than using them for research. In this paper, we examine the validity of the purported moral distinction between primates and other animals, and analyze the ethical acceptability of using primates to create organs for human use.

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Year:  2014        PMID: 24807743     DOI: 10.1007/s11019-014-9565-x

Source DB:  PubMed          Journal:  Med Health Care Philos        ISSN: 1386-7423


  5 in total

1.  Experimental use of nonhuman primates is not a simple problem.

Authors:  Niall Shanks; Ray Greek
Journal:  Nat Med       Date:  2008-10       Impact factor: 53.440

2.  Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells.

Authors:  Toshihiro Kobayashi; Tomoyuki Yamaguchi; Sanae Hamanaka; Megumi Kato-Itoh; Yuji Yamazaki; Makoto Ibata; Hideyuki Sato; Youn-Su Lee; Jo-Ichi Usui; A S Knisely; Masumi Hirabayashi; Hiromitsu Nakauchi
Journal:  Cell       Date:  2010-09-03       Impact factor: 41.582

3.  Formation of a thymus from rat ES cells in xenogeneic nude mouse↔rat ES chimeras.

Authors:  Ayako Isotani; Hide Hatayama; Kazuhiro Kaseda; Masahito Ikawa; Masaru Okabe
Journal:  Genes Cells       Date:  2011-03-15       Impact factor: 1.891

Review 4.  Xenotransplantation and risks of zoonotic infections.

Authors:  Roumiana S Boneva; Thomas M Folks
Journal:  Ann Med       Date:  2004       Impact factor: 4.709

5.  Strategies to enhance the safety profile of xenotransplantation: minimizing the risk of viral zoonoses.

Authors:  Giada Mattiuzzo; Linda Scobie; Yasuhiro Takeuchi
Journal:  Curr Opin Organ Transplant       Date:  2008-04       Impact factor: 2.640

  5 in total
  4 in total

Review 1.  Livestock models for exploiting the promise of pluripotent stem cells.

Authors:  R Michael Roberts; Ye Yuan; Nicholas Genovese; Toshihiko Ezashi
Journal:  ILAR J       Date:  2015

2.  The ethics of killing human/great-ape chimeras for their organs: a reply to Shaw et al.

Authors:  César Palacios-González
Journal:  Med Health Care Philos       Date:  2016-06

3.  A framework for the ethical assessment of chimeric animal research involving human neural tissue.

Authors:  Sebastian Porsdam Mann; Rosa Sun; Göran Hermerén
Journal:  BMC Med Ethics       Date:  2019-01-25       Impact factor: 2.652

4.  Ethical arguments concerning human-animal chimera research: a systematic review.

Authors:  Koko Kwisda; Lucie White; Dietmar Hübner
Journal:  BMC Med Ethics       Date:  2020-03-23       Impact factor: 2.652

  4 in total

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