PROBLEM: Previous studies have investigated the utility of inflammation markers as predictors of preterm birth, but none have compared trends in levels between uncomplicated and preterm pregnancy. METHOD OF STUDY: We explored longitudinal changes in plasma cytokines, including IL-1β, IL-6, IL-10, and TNF-α, as well as C-reactive protein in pregnant women from a nested case-control study. RESULTS: IL-6 was associated with increased odds of spontaneous preterm birth, defined by presentation of spontaneous preterm labor and/or preterm premature rupture of the membranes. Associations were strongest later in pregnancy. IL-10 was associated with increased odds of placentally mediated preterm birth, defined by presentation with preeclampsia or intrauterine growth restriction, and odds ratios were also highest near the end of pregnancy. CONCLUSION: Maternal inflammation markers were associated with increased risk of preterm birth, and relationships differed by etiology of preterm delivery and gestational age at sample collection.
PROBLEM: Previous studies have investigated the utility of inflammation markers as predictors of preterm birth, but none have compared trends in levels between uncomplicated and preterm pregnancy. METHOD OF STUDY: We explored longitudinal changes in plasma cytokines, including IL-1β, IL-6, IL-10, and TNF-α, as well as C-reactive protein in pregnant women from a nested case-control study. RESULTS:IL-6 was associated with increased odds of spontaneous preterm birth, defined by presentation of spontaneous preterm labor and/or preterm premature rupture of the membranes. Associations were strongest later in pregnancy. IL-10 was associated with increased odds of placentally mediated preterm birth, defined by presentation with preeclampsia or intrauterine growth restriction, and odds ratios were also highest near the end of pregnancy. CONCLUSION:Maternal inflammation markers were associated with increased risk of preterm birth, and relationships differed by etiology of preterm delivery and gestational age at sample collection.
Authors: Thomas A Pearson; George A Mensah; R Wayne Alexander; Jeffrey L Anderson; Richard O Cannon; Michael Criqui; Yazid Y Fadl; Stephen P Fortmann; Yuling Hong; Gary L Myers; Nader Rifai; Sidney C Smith; Kathryn Taubert; Russell P Tracy; Frank Vinicor Journal: Circulation Date: 2003-01-28 Impact factor: 29.690
Authors: Roberto Romero; Jimmy Espinoza; Luís F Gonçalves; Juan Pedro Kusanovic; Lara Friel; Sonia Hassan Journal: Semin Reprod Med Date: 2007-01 Impact factor: 1.303
Authors: Hannah H Chang; Jim Larson; Hannah Blencowe; Catherine Y Spong; Christopher P Howson; Sarah Cairns-Smith; Eve M Lackritz; Shoo K Lee; Elizabeth Mason; Andrew C Serazin; Salimah Walani; Joe Leigh Simpson; Joy E Lawn Journal: Lancet Date: 2012-11-16 Impact factor: 79.321
Authors: Margaret Harper; Liwu Li; Yuan Zhao; Mark A Klebanoff; John M Thorp; Yoram Sorokin; Michael W Varner; Ronald J Wapner; Steve N Caritis; Jay D Iams; Marshall W Carpenter; Alan M Peaceman; Brian M Mercer; Anthony Sciscione; Dwight J Rouse; Susan M Ramin; Garland D Anderson Journal: Obstet Gynecol Date: 2013-04 Impact factor: 7.661
Authors: Kelly K Ferguson; John D Meeker; Thomas F McElrath; Bhramar Mukherjee; David E Cantonwine Journal: Am J Obstet Gynecol Date: 2016-12-30 Impact factor: 8.661
Authors: Lindsey A Sjaarda; Rose G Radin; Chandra Swanson; Daniel L Kuhr; Sunni L Mumford; Noya Galai; Robert M Silver; Jean Wactawski-Wende; Neil J Perkins; Enrique F Schisterman Journal: Paediatr Perinat Epidemiol Date: 2017-09-15 Impact factor: 3.980
Authors: Emma Robertson Blackmore; Mona Mittal; Xueya Cai; Jan A Moynihan; Monica M Matthieu; Thomas G O'Connor Journal: J Womens Health (Larchmt) Date: 2016-01-08 Impact factor: 2.681