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Literature DB >> 24807298

The multivalent effect in glycosidase inhibition: a new, rapidly emerging topic in glycoscience.

Abstract

A bunch of keys, one lock: The multivalent effect in glycosidase inhibition is a new, rapidly emerging area with exciting potential and scope. This review presents a description of the different types of neoglycoclusters and their evaluation as glycosidase inhibitors. The first promising therapeutic applications are discussed, as well as the mechanisms underlying the observed inhibitory multivalent effect.

Keywords: click chemistry; glycosidases; iminosugars; inhibitors; multivalency

Mesh：

Substances：

Year: 2014 PMID： 24807298 DOI： 10.1002/cbic.201402026

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

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Cited

13 in total

1. Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores.

Authors: Mathieu L Lepage; Antoine Mirloup; Manon Ripoll; Fabien Stauffert; Anne Bodlenner; Raymond Ziessel; Philippe Compain
Journal: Beilstein J Org Chem Date: 2015-05-06 Impact factor: 2.883

2. Synthesis of divalent ligands of β-thio- and β-N-galactopyranosides and related lactosides and their evaluation as substrates and inhibitors of Trypanosoma cruzi trans-sialidase.

Authors: María Emilia Cano; Rosalía Agusti; Alejandro J Cagnoni; María Florencia Tesoriero; José Kovensky; María Laura Uhrig; Rosa M de Lederkremer
Journal: Beilstein J Org Chem Date: 2014-12-19 Impact factor: 2.883

Review 3. Recent advances in engineering polyvalent biological interactions.

Authors: Chad T Varner; Tania Rosen; Jacob T Martin; Ravi S Kane
Journal: Biomacromolecules Date: 2014-11-26 Impact factor: 6.988

4. Synthesis and Glycosidase Inhibition Properties of Calix[8]arene-Based Iminosugar Click Clusters.

Authors: Jérémy P Schneider; Stefano Tommasone; Paolo Della Sala; Carmine Gaeta; Carmen Talotta; Céline Tarnus; Placido Neri; Anne Bodlenner; Philippe Compain
Journal: Pharmaceuticals (Basel) Date: 2020-11-05

5. Monitoring glycosidase activity for clustered sugar substrates, a study on β-glucuronidase.

Authors: Yoan Brissonnet; Guillaume Compain; Brigitte Renoux; Eva-Maria Krammer; Franck Daligault; David Deniaud; Sébastien Papot; Sébastien G Gouin
Journal: RSC Adv Date: 2019-12-04 Impact factor: 4.036

6. Bambus[4,6]urils as Dual Scaffolds for Multivalent Iminosugar Presentation and Ion Transport: Access to Unprecedented Glycosidase-Directed Anion Caging Agents.

Authors: Marine Lafosse; Yan Liang; Jérémy P Schneider; Elise Cartier; Anne Bodlenner; Philippe Compain; Marie-Pierre Heck
Journal: Molecules Date: 2022-07-26 Impact factor: 4.927

The multivalent effect in glycosidase inhibition: a new, rapidly emerging topic in glycoscience.

1. Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores.

2. Synthesis of divalent ligands of β-thio- and β-N-galactopyranosides and related lactosides and their evaluation as substrates and inhibitors of Trypanosoma cruzi trans-sialidase.

Review 3. Recent advances in engineering polyvalent biological interactions.

4. Synthesis and Glycosidase Inhibition Properties of Calix[8]arene-Based Iminosugar Click Clusters.

5. Monitoring glycosidase activity for clustered sugar substrates, a study on β-glucuronidase.

6. Bambus[4,6]urils as Dual Scaffolds for Multivalent Iminosugar Presentation and Ion Transport: Access to Unprecedented Glycosidase-Directed Anion Caging Agents.

7. Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores.

8. Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar.

Review 9. Pyrrolizidine Alkaloids: Biosynthesis, Biological Activities and Occurrence in Crop Plants.

Review 10. Synthesis and Therapeutic Applications of Iminosugars in Cystic Fibrosis.