Literature DB >> 2480694

Expression of proto-oncogene products during drug-induced differentiation of a neuroblastoma cell line SK-N-DZ.

M Matsumoto1, T Akiyama, S Miyatake, Y Oda, H Kikuchi, M Hanaoka, Y Namba.   

Abstract

Four human neuroblastoma cell lines exhibited differences in their ability to differentiate into neuron-like cells in response to three different treatments, serum deprivation, or additions of dibutyryl cyclic-AMP or retinoic acid. Expression of N-myc gene product was reduced in neuroblastoma cell line SK-N-DZ differentiated by retinoic acid as compared with untreated cells. On the contrary, expression of c-src gene product, pp60c-src, was considerably enhanced in differentiated SK-N-DZ cells. Tyrosine phosphorylation of several cellular proteins was found to be enhanced in differentiated cells. Alteration in expression of these proto-oncogene products might be important in the differentiation of neuroblastoma cells into neuron-like cells.

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Year:  1989        PMID： 2480694     DOI： 10.1007/bf00294382

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  17 in total

1.  Induction of altered c-src product during neural differentiation of embryonal carcinoma cells.

Authors:  S A Lynch; J S Brugge; J M Levine
Journal:  Science       Date:  1986-11-14       Impact factor: 47.728

Review 2.  A human retinoic acid receptor which belongs to the family of nuclear receptors.

Authors:  M Petkovich; N J Brand; A Krust; P Chambon
Journal:  Nature       Date:  1987 Dec 3-9       Impact factor: 49.962

3.  The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA.

Authors:  J B Levy; T Dorai; L H Wang; J S Brugge
Journal:  Mol Cell Biol       Date:  1987-11       Impact factor: 4.272

4.  Developmental expression of two forms of pp60c-src in mouse brain.

Authors:  O D Wiestler; G Walter
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

5.  Do infants with stage IV-S neuroblastoma need treatment?

Authors:  A E Evans; E Baum; R Chard
Journal:  Arch Dis Child       Date:  1981-04       Impact factor: 3.791

6.  Neurones express high levels of a structurally modified, activated form of pp60c-src.

Authors:  J S Brugge; P C Cotton; A E Queral; J N Barrett; D Nonner; R W Keane
Journal:  Nature       Date:  1985 Aug 8-14       Impact factor: 49.962

7.  Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma.

Authors:  M Schwab; J Ellison; M Busch; W Rosenau; H E Varmus; J M Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

8.  Differential expression of myc family genes during murine development.

Authors:  K A Zimmerman; G D Yancopoulos; R G Collum; R K Smith; N E Kohl; K A Denis; M M Nau; O N Witte; D Toran-Allerand; C E Gee
Journal:  Nature       Date:  1986 Feb 27-Mar 5       Impact factor: 49.962

9.  Expression of c-src in cultured human neuroblastoma and small-cell lung carcinoma cell lines correlates with neurocrine differentiation.

Authors:  K Mellström; C Bjelfman; U Hammerling; S Påhlman
Journal:  Mol Cell Biol       Date:  1987-12       Impact factor: 4.272

10.  Activation of the pp60c-src kinase during differentiation of monomyelocytic cells in vitro.

Authors:  A Barnekow; M Gessler
Journal:  EMBO J       Date:  1986-04       Impact factor: 11.598
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  8 in total

1.  Correlation between nucleolar organizer region score and bromodeoxyuridine labeling index in C6 glioma cell line.

Authors:  A Hara; S Niikawa; H Hirayama; N Sakai; H Yamada; T Ohno; T Tanaka; H Mori
Journal:  J Neurooncol       Date:  1991-10       Impact factor: 4.130

2.  AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia.

Authors:  Eliana Gonçalves-Alves; Marta Garcia; Carlos J Rodríguez-Hernández; Soledad Gómez-González; Rupert C Ecker; Mariona Suñol; Oscar Muñoz-Aznar; Angel M Carcaboso; Jaume Mora; Cinzia Lavarino; Silvia Mateo-Lozano
Journal:  Int J Mol Sci       Date:  2022-04-13       Impact factor: 6.208

3.  Reconstitution of Schwannian stroma in neuroblastomas using human bone marrow stromal cells.

Authors:  Wenlin Du; Nobumichi Hozumi; Michiie Sakamoto; Jun-ichi Hata; Taketo Yamada
Journal:  Am J Pathol       Date:  2008-09-04       Impact factor: 4.307

Review 4.  Neuroblastoma and MYCN.

Authors:  Miller Huang; William A Weiss
Journal:  Cold Spring Harb Perspect Med       Date:  2013-10-01       Impact factor: 6.915

5.  Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment.

Authors:  Jon Celay; Idoia Blanco; Paula Lázcoz; Mirja Rotinen; Javier S Castresana; Ignacio Encío
Journal:  PLoS One       Date:  2013-05-01       Impact factor: 3.240

6.  Versican G1 domain enhances adenoviral-mediated transgene expression and can be modulated by inhibitors of the Janus kinase (JAK)/STAT and Src family kinase pathways.

Authors:  Patricia Y Akinfenwa; Wesley S Bond; Cristhian J Ildefonso; Mary Y Hurwitz; Richard L Hurwitz
Journal:  J Biol Chem       Date:  2017-07-06       Impact factor: 5.157

7.  microRNA-2110 functions as an onco-suppressor in neuroblastoma by directly targeting Tsukushi.

Authors:  Zhenze Zhao; Veronica Partridge; Michaela Sousares; Spencer D Shelton; Cory L Holland; Alexander Pertsemlidis; Liqin Du
Journal:  PLoS One       Date:  2018-12-14       Impact factor: 3.240

8.  Expression of MYCN in Multipotent Sympathoadrenal Progenitors Induces Proliferation and Neural Differentiation, but Is Not Sufficient for Tumorigenesis.

Authors:  Bret C Mobley; Minjae Kwon; Bradley R Kraemer; F Edward Hickman; Jingbo Qiao; Dai H Chung; Bruce D Carter
Journal:  PLoS One       Date:  2015-07-29       Impact factor: 3.240
  8 in total

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