Literature DB >> 2480578

Use-dependent effects of 4-aminopyridine on transient outward current in dog ventricular muscle.

J Simurda1, M Simurdová, G Christé.   

Abstract

The use-dependent features of 4-aminopyridine-induced block of the transient outward current were investigated under voltage clamp conditions in dog ventricular myocardial bundles. The block depended strongly on the pattern of voltage clamp pulses. Its level (settled in rested membranes) became deeper at early time during depolarization. In contrast, prolonged depolarization (above 50 to 100 ms) produced relief of block. Our results suggest that the block strongly depends on the state of the channel gating system.

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Year:  1989        PMID： 2480578     DOI： 10.1007/bf00370600

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  11 in total

1.  The effect of internal and external 4-aminopyridine on the potassium currents in intracellularly perfused squid giant axons.

Authors:  H Meves; Y Pichon
Journal:  J Physiol       Date:  1977-06       Impact factor: 5.182

2.  Two types of transient outward currents in adult human atrial cells.

Authors:  D Escande; A Coulombe; J F Faivre; E Deroubaix; E Coraboeuf
Journal:  Am J Physiol       Date:  1987-01

3.  Early outward current in rat single ventricular cells.

Authors:  I R Josephson; J Sanchez-Chapula; A M Brown
Journal:  Circ Res       Date:  1984-02       Impact factor: 17.367

4.  Block of potassium channels of the nodal membrane by 4-aminopyridine and its partial removal on depolarization.

Authors:  W Ulbricht; H H Wagner
Journal:  Pflugers Arch       Date:  1976-11-30       Impact factor: 3.657

5.  4-Aminopyridine sensitive transient outward current in dog ventricular fibres.

Authors:  J Simurda; M Simurdová; P Cupera
Journal:  Pflugers Arch       Date:  1988-04       Impact factor: 3.657

6.  Existence of two transient outward currents in sheep cardiac Purkinje fibers.

Authors:  E Coraboeuf; E Carmeliet
Journal:  Pflugers Arch       Date:  1982-02       Impact factor: 3.657

7.  A transient outward current in isolated cells from the crista terminalis of rabbit heart.

Authors:  W R Giles; A C van Ginneken
Journal:  J Physiol       Date:  1985-11       Impact factor: 5.182

8.  4-Aminopyridine and the early outward current of sheep cardiac Purkinje fibers.

Authors:  J L Kenyon; W R Gibbons
Journal:  J Gen Physiol       Date:  1979-02       Impact factor: 4.086

9.  Aminopyridine block of transient potassium current.

Authors:  S Thompson
Journal:  J Gen Physiol       Date:  1982-07       Impact factor: 4.086

10.  Dynamics of aminopyridine block of potassium channels in squid axon membrane.

Authors:  J Z Yeh; G S Oxford; C H Wu; T Narahashi
Journal:  J Gen Physiol       Date:  1976-11       Impact factor: 4.086
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  13 in total

1.  Possible involvement of a chloride conductance in the transient outward current of whole-cell voltage-clamped ferret ventricular myocytes.

Authors:  A Bouron; D Potreau; G Raymond
Journal:  Pflugers Arch       Date:  1991-11       Impact factor: 3.657

2.  Modulation of 4-AP block of a mammalian A-type K channel clone by channel gating and membrane voltage.

Authors:  J A Yao; G N Tseng
Journal:  Biophys J       Date:  1994-07       Impact factor: 4.033

3.  Mechanism of inhibition of delayed rectifier K+ current by 4-aminopyridine in rabbit coronary myocytes.

Authors:  C V Remillard; N Leblanc
Journal:  J Physiol       Date:  1996-03-01       Impact factor: 5.182

4.  On the mechanism by which 4-Aminopyridine occludes quinidine block of the cardiac K+ channel, hKv1.5.

Authors:  F S Chen; D Fedida
Journal:  J Gen Physiol       Date:  1998-04       Impact factor: 4.086

5.  Block by 4-aminopyridine of a Kv1.2 delayed rectifier K+ current expressed in Xenopus oocytes.

Authors:  S N Russell; N G Publicover; P J Hart; A Carl; J R Hume; K M Sanders; B Horowitz
Journal:  J Physiol       Date:  1994-12-15       Impact factor: 5.182

6.  Differential inhibition of a transient K+ current by chlorpromazine and 4-aminopyridine in neurones of the rat dorsal root ganglia.

Authors:  N Ogata; H Tatebayashi
Journal:  Br J Pharmacol       Date:  1993-08       Impact factor: 8.739

7.  Interaction of 4-aminopyridine with normal and chloramine-T-modified K channels of neuroblastoma cells.

Authors:  J M Dubois; B Rouzaire-Dubois
Journal:  Pflugers Arch       Date:  1991-08       Impact factor: 3.657

8.  A voltage-dependent potassium current in rabbit coronary artery smooth muscle cells.

Authors:  K A Volk; J J Matsuda; E F Shibata
Journal:  J Physiol       Date:  1991-08       Impact factor: 5.182

9.  Bi-stable block by 4-aminopyridine of a transient K+ channel (Kv1.4) cloned from ferret ventricle and expressed in Xenopus oocytes.

Authors:  R L Rasmusson; Y Zhang; D L Campbell; M B Comer; R C Castellino; S Liu; H C Strauss
Journal:  J Physiol       Date:  1995-05-15       Impact factor: 5.182

10.  Different mechanisms of the inhibition of the transient outward current in rat ventricular myocytes.

Authors:  U Jahnel; P Klemm; H Nawrath
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-01       Impact factor: 3.000
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