OBJECTIVES: To evaluate the predictive value of muscle strength and physical performance in the oldest old for all-cause mortality; hospitalization; and the onset of disability, defined as a decline in activities of daily living (ADLs), independent of muscle mass, inflammatory markers, and comorbidities. DESIGN: A prospective, observational, population-based follow-up study. SETTING: Three well-circumscribed areas of Belgium. PARTICIPANTS: Five hundred sixty participants aged 80 and older were followed for 33.5 months (interquartile range 31.1-35.6 months). MEASUREMENTS: Grip strength, Short Physical Performance Battery (SPPB) score, and muscle mass were measured at baseline; ADLs at baseline and after 20 months; and all-cause mortality and time to first hospitalization from inclusion onward. Kaplan-Meier curves and Cox proportional hazards models were calculated for all-cause mortality and hospitalization. Logistic regression analysis was used to determine predictors of decline in ADLs. RESULTS: Kaplan-Meier curves showed significantly higher all-cause mortality and hospitalization in subjects in the lowest tertile of grip strength and SPPB score. The adjusted Cox proportional hazards model showed that participants with high grip strength or a high SPPB score had a lower risk of mortality and hospitalization, independent of muscle mass, inflammatory markers, and comorbidity. A relationship was found between SPPB score and decline in ADLs, independent of muscle mass, inflammation, and comorbidity. CONCLUSION: In people aged 80 and older, physical performance is a strong predictor of mortality, hospitalization, and disability, and muscle strength is a strong predictor of mortality and hospitalization. All of these relationships were independent of muscle mass, inflammatory markers, and comorbidity.
OBJECTIVES: To evaluate the predictive value of muscle strength and physical performance in the oldest old for all-cause mortality; hospitalization; and the onset of disability, defined as a decline in activities of daily living (ADLs), independent of muscle mass, inflammatory markers, and comorbidities. DESIGN: A prospective, observational, population-based follow-up study. SETTING: Three well-circumscribed areas of Belgium. PARTICIPANTS: Five hundred sixty participants aged 80 and older were followed for 33.5 months (interquartile range 31.1-35.6 months). MEASUREMENTS: Grip strength, Short Physical Performance Battery (SPPB) score, and muscle mass were measured at baseline; ADLs at baseline and after 20 months; and all-cause mortality and time to first hospitalization from inclusion onward. Kaplan-Meier curves and Cox proportional hazards models were calculated for all-cause mortality and hospitalization. Logistic regression analysis was used to determine predictors of decline in ADLs. RESULTS: Kaplan-Meier curves showed significantly higher all-cause mortality and hospitalization in subjects in the lowest tertile of grip strength and SPPB score. The adjusted Cox proportional hazards model showed that participants with high grip strength or a high SPPB score had a lower risk of mortality and hospitalization, independent of muscle mass, inflammatory markers, and comorbidity. A relationship was found between SPPB score and decline in ADLs, independent of muscle mass, inflammation, and comorbidity. CONCLUSION: In people aged 80 and older, physical performance is a strong predictor of mortality, hospitalization, and disability, and muscle strength is a strong predictor of mortality and hospitalization. All of these relationships were independent of muscle mass, inflammatory markers, and comorbidity.
Authors: Carlo Custodero; Stephen D Anton; Daniel P Beavers; Robert T Mankowski; Stephanie A Lee; Mary M McDermott; Roger A Fielding; Anne B Newman; Russel P Tracy; Stephen B Kritchevsky; Walter T Ambrosius; Marco Pahor; Todd M Manini Journal: Arch Gerontol Geriatr Date: 2020-05-30 Impact factor: 3.250
Authors: Elizabeth R Pfoh; Amy W Wozniak; Elizabeth Colantuoni; Victor D Dinglas; Pedro A Mendez-Tellez; Carl Shanholtz; Nancy D Ciesla; Peter J Pronovost; Dale M Needham Journal: Intensive Care Med Date: 2016-09-16 Impact factor: 17.440
Authors: Cameron J Mitchell; Randall F D'Souza; Sarah M Mitchell; Vandre C Figueiredo; Benjamin F Miller; Karyn L Hamilton; Fredrick F Peelor; Marcelli Coronet; Chantal A Pileggi; Brenan Durainayagam; Aaron C Fanning; Sally D Poppitt; David Cameron-Smith Journal: J Appl Physiol (1985) Date: 2017-11-09
Authors: J Fernandes de Souza Barbosa; C Dos Santos Gomes; J Vilton Costa; T Ahmed; M V Zunzunegui; C-L Curcio; F Gomez; R Oliveira Guerra Journal: J Nutr Health Aging Date: 2018 Impact factor: 4.075
Authors: Lara Bianchi; Luigi Ferrucci; Antonio Cherubini; Marcello Maggio; Stefania Bandinelli; Elisabetta Savino; Gloria Brombo; Giovanni Zuliani; Jack M Guralnik; Francesco Landi; Stefano Volpato Journal: J Gerontol A Biol Sci Med Sci Date: 2015-09-02 Impact factor: 6.053