Literature DB >> 2480249

Poly(ADP-ribose) polymerase activity is inhibited by 2',5'-oligoadenylates in mouse L-cells.

D T Buonamassa1, M Malanga, E M Coccia, G Romeo, E Affabris, B Farina, H Suzuki.   

Abstract

Down regulation of poly(ADP-ribose)polymerase (ADPRP) activity was observed in mouse LW-cells after treatment with 2'-5'oligoadenylates or with fibroblast interferon and poly(rI) poly(rC). The poly(rI) poly(rC)-induced inhibition of the enzymatic activity correlates with the observed increase of endogenous 2',5'-oligoadenylate cores which were reported to be potent inhibitors of ADPRP in vitro.

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Year:  1989        PMID: 2480249     DOI: 10.1016/0014-5793(89)81641-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  1 in total

1.  Inverse relationship between poly (ADP-ribose) polymerase activity and 2',5'-oligoadenylates core level in estrogen-treated immature rat.

Authors:  H Suzuki; D Tornese Buonamassa; A Weisz
Journal:  Mol Cell Biochem       Date:  1990-12-03       Impact factor: 3.396

  1 in total

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