BACKGROUND: Aerosol-mediated delivery of nano-based therapeutics to the lung has emerged as a promising alternative for treatment and prevention of lung diseases. Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted significant attention for such applications due to their biocompatibility and magnetic properties. However, information is lacking about the characteristics of nebulized SPIONs for use as a therapeutic aerosol. To address this need, we conducted a physicochemical characterization of nebulized Rienso, a SPION-based formulation for intravenous treatment of anemia. METHODS: Four different concentrations of SPION suspensions were nebulized with a one-jet nebulizer. Particle size was measured in suspension by transmission electron microscopy (TEM), photon correlation spectroscopy (PCS), and nanoparticle tracking analysis (NTA), and in the aerosol by a scanning mobility particle sizer (SMPS). RESULTS: The average particle size in suspension as measured by TEM, PCS, and NTA was 9±2 nm, 27±7 nm, and 56±10 nm, respectively. The particle size in suspension remained the same before and after the nebulization process. However, after aerosol collection in an impinger, the suspended particle size increased to 159±46 nm as measured by NTA. The aerosol particle concentration increased linearly with increasing suspension concentration, and the aerodynamic diameter remained relatively stable at around 75 nm as measured by SMPS. CONCLUSIONS: We demonstrated that the total number and particle size in the aerosol were modulated as a function of the initial concentration in the nebulizer. The data obtained mark the first known independent characterization of nebulized Rienso and, as such, provide critical information on the behavior of Rienso nanoparticles in an aerosol. The data obtained in this study add new knowledge to the existing body of literature on potential applications of SPION suspensions as inhaled aerosol therapeutics.
BACKGROUND: Aerosol-mediated delivery of nano-based therapeutics to the lung has emerged as a promising alternative for treatment and prevention of lung diseases. Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted significant attention for such applications due to their biocompatibility and magnetic properties. However, information is lacking about the characteristics of nebulized SPIONs for use as a therapeutic aerosol. To address this need, we conducted a physicochemical characterization of nebulized Rienso, a SPION-based formulation for intravenous treatment of anemia. METHODS: Four different concentrations of SPION suspensions were nebulized with a one-jet nebulizer. Particle size was measured in suspension by transmission electron microscopy (TEM), photon correlation spectroscopy (PCS), and nanoparticle tracking analysis (NTA), and in the aerosol by a scanning mobility particle sizer (SMPS). RESULTS: The average particle size in suspension as measured by TEM, PCS, and NTA was 9±2 nm, 27±7 nm, and 56±10 nm, respectively. The particle size in suspension remained the same before and after the nebulization process. However, after aerosol collection in an impinger, the suspended particle size increased to 159±46 nm as measured by NTA. The aerosol particle concentration increased linearly with increasing suspension concentration, and the aerodynamic diameter remained relatively stable at around 75 nm as measured by SMPS. CONCLUSIONS: We demonstrated that the total number and particle size in the aerosol were modulated as a function of the initial concentration in the nebulizer. The data obtained mark the first known independent characterization of nebulized Rienso and, as such, provide critical information on the behavior of Rienso nanoparticles in an aerosol. The data obtained in this study add new knowledge to the existing body of literature on potential applications of SPION suspensions as inhaled aerosol therapeutics.
Authors: P F Hahn; D D Stark; J M Lewis; S Saini; G Elizondo; R Weissleder; C J Fretz; J T Ferrucci Journal: Radiology Date: 1990-06 Impact factor: 11.105
Authors: Philippe Bourrinet; Howard H Bengele; Bruno Bonnemain; Anne Dencausse; Jean-Marc Idee; Paula M Jacobs; Jerome M Lewis Journal: Invest Radiol Date: 2006-03 Impact factor: 6.016
Authors: Natalia L Chaves; Irina Estrela-Lopis; Julia Böttner; Cláudio Ap Lopes; Bruna C Guido; Aparecido R de Sousa; Sônia N Báo Journal: Int J Nanomedicine Date: 2017-08-02
Authors: Ryan P Badman; Shanna L Moore; Jessica L Killian; Tuancheng Feng; Thomas A Cleland; Fenghua Hu; Michelle D Wang Journal: Sci Rep Date: 2020-07-08 Impact factor: 4.379
Authors: David Chang; May Lim; Jeroen A C M Goos; Ruirui Qiao; Yun Yee Ng; Friederike M Mansfeld; Michael Jackson; Thomas P Davis; Maria Kavallaris Journal: Front Pharmacol Date: 2018-08-02 Impact factor: 5.810
Authors: Stephen J Evans; Martin J D Clift; Neenu Singh; John W Wills; Nicole Hondow; Thomas S Wilkinson; Michael J Burgum; Andy P Brown; Gareth J Jenkins; Shareen H Doak Journal: Part Fibre Toxicol Date: 2019-02-13 Impact factor: 9.400
Authors: Andi Setiono; Maik Bertke; Wilson Ombati Nyang'au; Jiushuai Xu; Michael Fahrbach; Ina Kirsch; Erik Uhde; Alexander Deutschinger; Ernest J Fantner; Christian H Schwalb; Hutomo Suryo Wasisto; Erwin Peiner Journal: Sensors (Basel) Date: 2020-01-22 Impact factor: 3.576