| Literature DB >> 24801835 |
Hong Jiang1, Ping Wang2, Xiaohua Li3, Qilong Wang4, Zhong-Bin Deng4, Xiaoying Zhuang4, Jingyao Mu4, Lifeng Zhang4, Baomei Wang4, Jun Yan4, Donald Miller4, Huang-Ge Zhang5.
Abstract
Aberrant microRNA (miRNA) expression has been identified in various human solid cancers. However, whether the levels of miRNA expression in tumor cells have any effect on tumor progression has not been determined. In this proof-of-concept study, the restoration of high-level expression of the miR17-92 cluster of miRNAs reveals its function as a tumor suppressor in murine solid cancer cells. Specifically, genetically engineered expression of higher levels of miR17/20a in the miR17-92 cluster in both murine breast cancer and colon cancer cells triggered natural killer (NK)-cell recognition by inhibiting the expression of MHC class I (H-2D) through the Mekk2-Mek5-Erk5 pathway. Results from the mouse tumor studies were recapitulated using samples of human solid tumors. Together, these data indicate that miR17/20a miRNAs function as tumor suppressors by reprogramming tumor cells for NK cell-mediated cytotoxicity. ©2014 American Association for Cancer Research.Entities:
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Year: 2014 PMID： 24801835 PMCID： PMC4396632 DOI： 10.1158/2326-6066.CIR-13-0162
Source DB: PubMed Journal: Cancer Immunol Res ISSN： 2326-6066 Impact factor: 11.151