BACKGROUND: Radiotherapy (XRT) exerts detrimental collateral effects on bone tissue through mechanisms of vascular damage and impediments to osteocytes, ultimately predisposing patients to the debilitating problems of late pathologic fractures and nonunions. We posit that angiogenic therapy will reverse these pathologic effects in a rat model of radiated fracture healing. METHODS: Three groups of rats underwent mandibular osteotomy. Radiated groups received a fractionated 35-Gy dose before surgery. The deferoxamine (DFO) group received local injections postoperatively. A 40-day healing period was allowed before histology. Analysis of variance (ANOVA; p < .05) was used for group comparisons. RESULTS: Radiated fractures revealed a significantly decreased osteocyte count and corresponding increase in empty lacunae when compared to nonradiated fractures (p = .001). With the addition of DFO, these differences were not appreciated. Further, a 42% increase in bony unions was observed after DFO therapy. CONCLUSION: Targeting angiogenesis is a useful means for promoting osteocyte survival and preventing bone pathology after XRT.
BACKGROUND: Radiotherapy (XRT) exerts detrimental collateral effects on bone tissue through mechanisms of vascular damage and impediments to osteocytes, ultimately predisposing patients to the debilitating problems of late pathologic fractures and nonunions. We posit that angiogenic therapy will reverse these pathologic effects in a rat model of radiated fracture healing. METHODS: Three groups of rats underwent mandibular osteotomy. Radiated groups received a fractionated 35-Gy dose before surgery. The deferoxamine (DFO) group received local injections postoperatively. A 40-day healing period was allowed before histology. Analysis of variance (ANOVA; p < .05) was used for group comparisons. RESULTS:Radiated fractures revealed a significantly decreased osteocyte count and corresponding increase in empty lacunae when compared to nonradiated fractures (p = .001). With the addition of DFO, these differences were not appreciated. Further, a 42% increase in bony unions was observed after DFO therapy. CONCLUSION: Targeting angiogenesis is a useful means for promoting osteocyte survival and preventing bone pathology after XRT.
Authors: Steven R Buchman; Michael A Ignelzi; Caius Radu; Jonathan Wilensky; Andrew H Rosenthal; Lawrence Tong; Samuel T Rhee; Steven A Goldstein Journal: Ann Plast Surg Date: 2002-11 Impact factor: 1.539
Authors: Christian Schmitt; Rainer Lutz; Hendrik Doering; Michael Lell; Jozsef Ratky; Karl Andreas Schlegel Journal: Clin Oral Implants Res Date: 2011-11-01 Impact factor: 5.977
Authors: John Street; Min Bao; Leo deGuzman; Stuart Bunting; Franklin V Peale; Napoleone Ferrara; Hope Steinmetz; John Hoeffel; Jeffrey L Cleland; Ann Daugherty; Nicholas van Bruggen; H Paul Redmond; Richard A D Carano; Ellen H Filvaroff Journal: Proc Natl Acad Sci U S A Date: 2002-07-12 Impact factor: 11.205
Authors: Xing Shen; Chao Wan; Girish Ramaswamy; Mahendra Mavalli; Ying Wang; Craig L Duvall; Lian Fu Deng; Robert E Guldberg; Alan Eberhart; Thomas L Clemens; Shawn R Gilbert Journal: J Orthop Res Date: 2009-10 Impact factor: 3.494
Authors: Alexis Donneys; Daniela M Weiss; Sagar S Deshpande; Salman Ahsan; Catherine N Tchanque-Fossuo; Deniz Sarhaddi; Benjamin Levi; Steven A Goldstein; Steven R Buchman Journal: Bone Date: 2012-10-18 Impact factor: 4.398
Authors: Kavitha Ranganathan; Eric Simon; Jeremy Lynn; Alicia Snider; Yu Zhang; Noah Nelson; Alexis Donneys; Jose Rodriguez; Lauren Buchman; Dawn Reyna; Elke Lipka; Steven R Buchman Journal: Pharm Res Date: 2018-03-19 Impact factor: 4.200
Authors: Alexis Donneys; Jordan T Blough; Noah S Nelson; Joseph E Perosky; Sagar S Deshpande; Stephen Y Kang; Peter A Felice; Christian Figueredo; Jonathan R Peterson; Kenneth M Kozloff; Benjamin Levi; Douglas B Chepeha; Steven R Buchman Journal: Head Neck Date: 2015-07-15 Impact factor: 3.147
Authors: Jeremy V Lynn; Kavitha Ranganathan; Kevin M Urlaub; Alexandra O Luby; Chris J Stephan; Alexis Donneys; Noah S Nelson; Steven R Buchman Journal: Ann Plast Surg Date: 2020-07 Impact factor: 1.763