Robert M Kessler1, John Seibyl2, Ronald L Cowan3, David Zald4, Jacob S Young4, Mohammad Sib Ansari3, Michael G Stabin3. 1. Vanderbilt University School of Medicine, Nashville, Tennessee rkessler@uabmc.edu. 2. Institute for Neurodegenerative Disorders, New Haven, Connecticut; and. 3. Vanderbilt University School of Medicine, Nashville, Tennessee. 4. Psychology, Vanderbilt University School of Arts and Sciences, Nashville, Tennessee.
Abstract
UNLABELLED: (18)F-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile ((18)F-FPEB) is a potent and specific radioligand for the metabotropic glutamate receptor subtype 5 (mGluR5). Before undertaking clinical research studies with (18)F-FPEB, we performed studies of human radiation dosimetry. METHODS: Serial whole-body scans were obtained in 9 healthy human subjects (5 men, 4 women) for 190-440 min after the intravenous administration of (18)F-FPEB. Radiation doses were estimated using the OLINDA/EXM software. RESULTS: Peak organ doses were to the urinary bladder wall, 0.258 mGy/MBq (0.955 rad/mCi), and gallbladder wall, 0.193 mGy/MBq (0.716 rad/mCi). The effective dose was 0.025 mSv/MBq (0.0922 rem/mCi). The doses to the red marrow and spleen were 0.00797 mGy/MBq (0.0295 rad/mCi) and 0.00709 mGy/MBq (0.0262 rad/mCi), respectively. Reducing the urinary voiding interval to 60 or 90 min lowered the urinary bladder wall dose to 0.0885 mGy/MBq (0.327 rad/mCi) or 0.128 mGy/MBq (0.473 rad/mCi), respectively, and the effective dose to 0.0149 mSv/MBq (0.0551 rem/mCi) or 0.0171 mSv/MBq (0.0634 rem/mCi), respectively. CONCLUSION: Urinary voiding should be performed during (18)F-FPEB studies to minimize radiation exposure to research subjects.
UNLABELLED: (18)F-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile ((18)F-FPEB) is a potent and specific radioligand for the metabotropic glutamate receptor subtype 5 (mGluR5). Before undertaking clinical research studies with (18)F-FPEB, we performed studies of human radiation dosimetry. METHODS: Serial whole-body scans were obtained in 9 healthy human subjects (5 men, 4 women) for 190-440 min after the intravenous administration of (18)F-FPEB. Radiation doses were estimated using the OLINDA/EXM software. RESULTS: Peak organ doses were to the urinary bladder wall, 0.258 mGy/MBq (0.955 rad/mCi), and gallbladder wall, 0.193 mGy/MBq (0.716 rad/mCi). The effective dose was 0.025 mSv/MBq (0.0922 rem/mCi). The doses to the red marrow and spleen were 0.00797 mGy/MBq (0.0295 rad/mCi) and 0.00709 mGy/MBq (0.0262 rad/mCi), respectively. Reducing the urinary voiding interval to 60 or 90 min lowered the urinary bladder wall dose to 0.0885 mGy/MBq (0.327 rad/mCi) or 0.128 mGy/MBq (0.473 rad/mCi), respectively, and the effective dose to 0.0149 mSv/MBq (0.0551 rem/mCi) or 0.0171 mSv/MBq (0.0634 rem/mCi), respectively. CONCLUSION: Urinary voiding should be performed during (18)F-FPEB studies to minimize radiation exposure to research subjects.
Authors: Se Jong Oh; Namhun Lee; Kyung Rok Nam; Kyung Jun Kang; Sang Jin Han; Kyo Chul Lee; Yong Jin Lee; Jae Yong Choi Journal: Front Neurosci Date: 2022-08-05 Impact factor: 5.152
Authors: James Robert Brašić; Jack Alexander Goodman; Ayon Nandi; David S Russell; Danna Jennings; Olivier Barret; Samuel D Martin; Keith Slifer; Thomas Sedlak; Anil Kumar Mathur; John P Seibyl; Elizabeth M Berry-Kravis; Dean F Wong; Dejan B Budimirovic Journal: Brain Sci Date: 2022-02-26