Literature DB >> 24799066

PIM kinases: an overview in tumors and recent advances in pancreatic cancer.

Jianwei Xu1, Taiping Zhang, Tianxiao Wang, Lei You, Yupei Zhao.   

Abstract

The PIM kinases represent a family of serine/threonine kinases, which is composed of three different members (PIM1, PIM2 and PIM3). Aberrant expression of PIM kinases is observed in variety of tumors, including pancreatic cancer. The PIM kinases play pivotal roles in the regulation of cell cycle, apoptosis, properties of stem cells, metabolism, autophagy, drug resistance and targeted therapy. The roles of PIM kinases in pancreatic cancer include the regulation of proliferation, apoptosis, cell cycle, formation, angiogenesis and prediction prognosis. Blocking the activities of PIM kinases could prevent pancreatic cancer development. PIM kinases may be a novel target for cancer therapy.

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Year:  2014        PMID： 24799066     DOI： 10.2217/fon.13.229

Source DB:  PubMed          Journal:  Future Oncol        ISSN： 1479-6694            Impact factor:   3.404


  15 in total

1.  High levels of glioma tumor suppressor candidate region gene 1 predicts a poor prognosis for prostate cancer.

Authors:  Xiaoming Ma; Tao Du; Dingjun Zhu; Xianju Chen; Yiming Lai; Wanhua Wu; Qiong Wang; Chunhao Lin; Zean Li; Leyuan Liu; Hai Huang
Journal:  Oncol Lett       Date:  2018-09-24       Impact factor: 2.967

2.  Androgen deprivation therapy has no effect on Pim-1 expression in a mouse model of prostate cancer.

Authors:  Jiang Wang; Gang Li; Bo Li; Hualin Song; Zhiqun Shang; Ning Jiang; Yuanjie Niu
Journal:  Oncol Lett       Date:  2017-04-07       Impact factor: 2.967

3.  MicroRNA-638 inhibits cell proliferation by targeting suppress PIM1 expression in human osteosarcoma.

Authors:  Xiao-Xu Wang; Jue Liu; Yi-Min Tang; Liang Hong; Zhi Zeng; Guang-Hua Tan
Journal:  Tumour Biol       Date:  2017-01-03

4.  PIM3 Promotes the Proliferation and Migration of Acute Myeloid Leukemia Cells.

Authors:  Hongmei Luo; Ruixue Sun; Yuhuan Zheng; Jingcao Huang; Fangfang Wang; Dan Long; Yu Wu
Journal:  Onco Targets Ther       Date:  2020-07-14       Impact factor: 4.147

5.  Human papillomavirus insertions identify the PIM family of serine/threonine kinases as targetable driver genes in head and neck squamous cell carcinoma.

Authors:  Tatevik R Broutian; Bo Jiang; Jingfeng Li; Keiko Akagi; Shanying Gui; Zhengqiu Zhou; Weihong Xiao; David E Symer; Maura L Gillison
Journal:  Cancer Lett       Date:  2020-01-17       Impact factor: 8.679

6.  PIM-1 contributes to the malignancy of pancreatic cancer and displays diagnostic and prognostic value.

Authors:  Jianwei Xu; Guangbing Xiong; Zhe Cao; Hua Huang; Tianxiao Wang; Lei You; Li Zhou; Lianfang Zheng; Ya Hu; Taiping Zhang; Yupei Zhao
Journal:  J Exp Clin Cancer Res       Date:  2016-09-05

7.  Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus.

Authors:  Manuel-Pedro Jiménez-García; Antonio Lucena-Cacace; María-José Robles-Frías; Irene Ferrer; Maja Narlik-Grassow; Carmen Blanco-Aparicio; Amancio Carnero
Journal:  Oncotarget       Date:  2017-07-22

Review 8.  Biomarkers and Targeted Therapy in Pancreatic Cancer.

Authors:  Fataneh Karandish; Sanku Mallik
Journal:  Biomark Cancer       Date:  2016-04-26

9.  Hypoxia-responsive miR-124 and miR-144 reduce hypoxia-induced autophagy and enhance radiosensitivity of prostate cancer cells via suppressing PIM1.

Authors:  Hao Gu; Mingzhu Liu; Changmao Ding; Xin Wang; Rui Wang; Xinyu Wu; Ruitai Fan
Journal:  Cancer Med       Date:  2016-03-14       Impact factor: 4.452

10.  MicroRNA-124-3p regulates cell proliferation, invasion, apoptosis, and bioenergetics by targeting PIM1 in astrocytoma.

Authors:  Danni Deng; Lei Wang; Yao Chen; Bowen Li; Lian Xue; Naiyuan Shao; Qiang Wang; Xiwei Xia; Yilin Yang; Feng Zhi
Journal:  Cancer Sci       Date:  2016-06-21       Impact factor: 6.518
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