Literature DB >> 24799056

CXCL12-CXCR4 contributes to the implication of bone marrow in cancer metastasis.

Jingsheng Shi1, Yibing Wei, Jun Xia, Siqun Wang, Jianguo Wu, Feiyan Chen, Gangyong Huang, Jie Chen.   

Abstract

The CXCL12-CXCR4 axis is postulated to be a key pathway in the interaction between (cancer) stem cells and their surrounding supportive cells in the (cancer) stem cell niche. As the bone marrow constitutes a unique microenvironment for cancer cells, the CXCL12-CXCR4 axis assists the bone marrow in regulating cancer progression. This interaction can be disrupted by CXCR4 antagonists, and this concept is being used clinically to harvest hematopoietic stem/progenitor cells from the bone marrow. The functions of CXCL12-CXCR4 axis in cancer cell-tumor microenvironment interaction and angiogenesis have been recently studied. This review focuses on how CXCL12-CXCR4 helps the bone marrow in creating a tumor mircoenvironment that results in the cancer metastasis. It also discusses ongoing research regarding the clinical feasibility of CXCR4 inhibitors.

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Year:  2014        PMID： 24799056     DOI： 10.2217/fon.13.193

Source DB:  PubMed          Journal:  Future Oncol        ISSN： 1479-6694            Impact factor:   3.404


  12 in total

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Authors:  Yongqian Fan; Fengjian Yang; Xuhai Cao; Cong Chen; Xuelin Zhang; Xu Zhang; Weilong Lin; Xiaofeng Wang; Chengwei Liang
Journal:  Tumour Biol       Date:  2015-08-16

Review 2.  Pancreatic cancer stem cell markers and exosomes - the incentive push.

Authors:  Sarah Heiler; Zhe Wang; Margot Zöller
Journal:  World J Gastroenterol       Date:  2016-07-14       Impact factor: 5.742

3.  A non-GPCR-binding partner interacts with a novel surface on β-arrestin1 to mediate GPCR signaling.

Authors:  Ya Zhuo; Vsevolod V Gurevich; Sergey A Vishnivetskiy; Candice S Klug; Adriano Marchese
Journal:  J Biol Chem       Date:  2020-08-04       Impact factor: 5.157

4.  The Comparison of Adipose Stem Cell and Placental Stem Cell in Secretion Characteristics and in Facial Antiaging.

Authors:  Yan Xu; Shilei Guo; Cui Wei; Honglan Li; Lei Chen; Chang Yin; Chuansen Zhang
Journal:  Stem Cells Int       Date:  2016-02-08       Impact factor: 5.443

5.  Chemokine receptor CXCR4 activates the RhoA/ROCK2 pathway in spinal neurons that induces bone cancer pain.

Authors:  Heng Xu; Chong Peng; Xue-Tai Chen; Ying-Ying Yao; Li-Ping Chen; Qin Yin; Wen Shen
Journal:  Mol Pain       Date:  2020 Jan-Dec       Impact factor: 3.395

6.  Development and Evaluation of an 18F-Radiolabeled Monocyclam Derivative for Imaging CXCR4 Expression.

Authors:  Diana Brickute; Marta Braga; Maciej A Kaliszczak; Chris Barnes; Doreen Lau; Laurence Carroll; Elizabeth Stevens; Sebastian Trousil; Israt S Alam; Quang-Dé Nguyen; Eric O Aboagye
Journal:  Mol Pharm       Date:  2019-04-03       Impact factor: 4.939

7.  Tumor-derived exosomes promote the in vitro osteotropism of melanoma cells by activating the SDF-1/CXCR4/CXCR7 axis.

Authors:  Francesco Mannavola; Marco Tucci; Claudia Felici; Anna Passarelli; Stella D'Oronzo; Francesco Silvestris
Journal:  J Transl Med       Date:  2019-07-19       Impact factor: 5.531

8.  The CXCR4-CXCL12-Axis Is of Prognostic Relevance in DLBCL and Its Antagonists Exert Pro-Apoptotic Effects In Vitro.

Authors:  Katrin Pansy; Julia Feichtinger; Barbara Ehall; Barbara Uhl; Miriam Sedej; David Roula; Beata Pursche; Axel Wolf; Manuel Zoidl; Elisabeth Steinbauer; Verena Gruber; Hildegard T Greinix; Katharina T Prochazka; Gerhard G Thallinger; Akos Heinemann; Christine Beham-Schmid; Peter Neumeister; Tanja M Wrodnigg; Karoline Fechter; Alexander Ja Deutsch
Journal:  Int J Mol Sci       Date:  2019-09-24       Impact factor: 5.923

9.  Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model.

Authors:  Claudia Tulotta; Cristina Stefanescu; Elena Beletkaia; Jeroen Bussmann; Katsiaryna Tarbashevich; Thomas Schmidt; B Ewa Snaar-Jagalska
Journal:  Dis Model Mech       Date:  2016-01-07       Impact factor: 5.758

10.  MicroRNA-126 inhibits colon cancer cell proliferation and invasion by targeting the chemokine (C-X-C motif) receptor 4 and Ras homolog gene family, member A, signaling pathway.

Authors:  Wei Yuan; Ye-Qing Guo; Xia-Yu Li; Min-Zi Deng; Zhao-Hua Shen; Chi-Bin Bo; Ya-Fei Dai; Ming-Yu Huang; Zhen-Yu Yang; Yong-Sheng Quan; Li Tian; Xiaoyan Wang
Journal:  Oncotarget       Date:  2016-09-13
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