Literature DB >> 24798526

Lessons learned from the Syrian sarin attack: evaluation of a clinical syndrome through social media.

Yossi Rosman, Arik Eisenkraft, Nadav Milk, Arthur Shiyovich, Nimrod Ophir, Shai Shrot, Yitshak Kreiss, Michael Kassirer.   

Abstract

On the night of 21 August 2013, sarin was dispersed in the eastern outskirts of Damascus, killing 1400 civilians and severely affecting thousands more. This article aims to delineate the clinical presentation and management of a mass casualty event caused by a nerve agent as shown in the social media. Authors searched YouTube for videos uploaded of this attack and identified 210 videos. Of these, 67 met inclusion criteria and were evaluated in the final analysis.These videos displayed 130 casualties; 119 (91.5%) of which were defined as moderately injured or worse. The most common clinical signs were dyspnea (53.0%), diaphoresis (48.5%), and loss of consciousness (40.7%). Important findings included a severe shortage of supporting measures and lack of antidotal autoinjectors. Decontamination, documented in 25% of the videos, was done in an inefficient manner. Protective gear was not noticed, except for sporadic use of latex gloves and surgical masks.This is believed to be the first time that social media was used to evaluate clinical data and management protocols to better prepare against future possible events.

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Year:  2014        PMID: 24798526     DOI: 10.7326/M13-2799

Source DB:  PubMed          Journal:  Ann Intern Med        ISSN: 0003-4819            Impact factor:   25.391


  36 in total

1.  The Little India riot: experience of an emergency department in Singapore.

Authors:  Wei Feng Lee; Chee Kheong Ooi; Dong Haur Phua; Ming Hai Eric Wong; Wui Ling Chan; Yih Yng Ng
Journal:  Singapore Med J       Date:  2015-12       Impact factor: 1.858

2.  The NIH Countermeasures Against Chemical Threats Program: overview and special challenges.

Authors:  David A Jett
Journal:  Ann N Y Acad Sci       Date:  2016-06       Impact factor: 5.691

Review 3.  Midazolam as an anticonvulsant antidote for organophosphate intoxication--A pharmacotherapeutic appraisal.

Authors:  Sandesh D Reddy; Doodipala Samba Reddy
Journal:  Epilepsia       Date:  2015-05-29       Impact factor: 5.864

4.  Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents.

Authors:  Xin Wu; Ramkumar Kuruba; Doodipala Samba Reddy
Journal:  J Pharmacol Exp Ther       Date:  2018-08-16       Impact factor: 4.030

5.  Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model.

Authors:  Marson Putra; Shaunik Sharma; Meghan Gage; Grace Gasser; Andy Hinojo-Perez; Ashley Olson; Adriana Gregory-Flores; Sreekanth Puttachary; Chong Wang; Vellareddy Anantharam; Thimmasettappa Thippeswamy
Journal:  Neurobiol Dis       Date:  2019-03-30       Impact factor: 5.996

6.  A century of chemical warfare: time to stop.

Authors:  Arik Eisenkraft; S David Gertz; Yitshak Kreiss
Journal:  CMAJ       Date:  2014-09-02       Impact factor: 8.262

7.  A national toxicology program systematic review of the evidence for long-term effects after acute exposure to sarin nerve agent.

Authors:  David A Jett; Christopher A Sibrizzi; Robyn B Blain; Pamela A Hartman; Pamela J Lein; Kyla W Taylor; Andrew A Rooney
Journal:  Crit Rev Toxicol       Date:  2020-08-05       Impact factor: 5.635

8.  Age-Related Susceptibility to Epileptogenesis and Neuronal Loss in Male Fischer Rats Exposed to Soman and Treated With Medical Countermeasures.

Authors:  Brenda Marrero-Rosado; Franco Rossetti; Matthew W Rice; Mark C Moffett; Robyn B Lee; Michael F Stone; Lucille A Lumley
Journal:  Toxicol Sci       Date:  2018-07-01       Impact factor: 4.849

Review 9.  Sarin (GB, O-isopropyl methylphosphonofluoridate) neurotoxicity: critical review.

Authors:  Mohamed B Abou-Donia; Briana Siracuse; Natasha Gupta; Ashly Sobel Sokol
Journal:  Crit Rev Toxicol       Date:  2016-10-05       Impact factor: 5.635

Review 10.  Possible role for anisodamine in organophosphate poisoning.

Authors:  Arik Eisenkraft; Avshalom Falk
Journal:  Br J Pharmacol       Date:  2016-04-22       Impact factor: 8.739

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