| Literature DB >> 24798244 |
Klemens Ruprecht1, Benjamin Wunderlich2, René Gieß2, Petra Meyer3, Madlen Loebel4, Klaus Lenz5, Jörg Hofmann6, Berit Rosche2, Oliver Wengert2, Friedemann Paul7, Ulf Reimer3, Carmen Scheibenbogen4.
Abstract
Patients with multiple sclerosis (MS) have elevated antibodies against Epstein-Barr virus (EBV), but data on the epitope-resolved specificity of these antibodies are scarce. Using a peptide microarray containing 1465 peptides representing 8 full-length EBV proteins, we identified higher (p<0.001) antibody reactivities to 39 EBV-peptides in MS patients (n=29) compared to healthy controls (n=22). Seventeen of the 39 peptides were from EBNA-1 and 13 located within the glycine-alanine repeat of EBNA-1. Further reactivities were directed against EBNA-3, EBNA-4, EBNA-6, VP26, and LMP1. Thus, antibodies against EBV in MS patients primarily target, but are not confined to, the glycine-alanine repeat of EBNA-1.Entities:
Keywords: Antibodies; Epstein–Barr nuclear antigen-1; Epstein–Barr virus; Glycine–alanine repeat; Multiple sclerosis; Peptide array
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Year: 2014 PMID： 24798244 DOI： 10.1016/j.jneuroim.2014.04.005
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478