UNLABELLED: Abstract Objective: The maternal-fetal interface must modulate immune function to allow tolerance of fetal cells while still reacting to pathogens to suppress infection. Human leukocyte antigen-G (HLA-G) is a class Ib major histocompatibility complex protein involved in maternal-fetal tolerance. We posited that alterations in placental HLA-G expression predispose women to preterm birth. The aim of this study was to compare HLA-G expression in the maternal-fetal interface of term versus preterm human placentas. METHODS: We performed a cross-sectional study of specimens from the basal plate of the human placenta from women enrolled in a tissue specimen and clinical data consortium. Immunohistochemistry with digital microscopic analysis was used to quantify HLA-G protein expression in the basal plate from preterm and term placentas. RESULTS: Preterm birth <37 weeks occurred in 29.5% of 149 singleton pregnancies. HLA-G-positive cells occupied one-third of the basal plates, and the HLA-G-positive area was increased by 14% in placentas from preterm births than in those from term births (32.1% in term placentas versus 36.6% in preterm placentas). CONCLUSION: Although HLA-G is required for maternal tolerance of the semi-allogeneic fetus, higher levels of HLA-G expression at the maternal-fetal interface is associated with preterm birth.
UNLABELLED: Abstract Objective: The maternal-fetal interface must modulate immune function to allow tolerance of fetal cells while still reacting to pathogens to suppress infection. Human leukocyte antigen-G (HLA-G) is a class Ib major histocompatibility complex protein involved in maternal-fetal tolerance. We posited that alterations in placental HLA-G expression predispose women to preterm birth. The aim of this study was to compare HLA-G expression in the maternal-fetal interface of term versus preterm human placentas. METHODS: We performed a cross-sectional study of specimens from the basal plate of the human placenta from women enrolled in a tissue specimen and clinical data consortium. Immunohistochemistry with digital microscopic analysis was used to quantify HLA-G protein expression in the basal plate from preterm and term placentas. RESULTS: Preterm birth <37 weeks occurred in 29.5% of 149 singleton pregnancies. HLA-G-positive cells occupied one-third of the basal plates, and the HLA-G-positive area was increased by 14% in placentas from preterm births than in those from term births (32.1% in term placentas versus 36.6% in preterm placentas). CONCLUSION: Although HLA-G is required for maternal tolerance of the semi-allogeneic fetus, higher levels of HLA-G expression at the maternal-fetal interface is associated with preterm birth.
Authors: S Fournel; M Aguerre-Girr; X Huc; F Lenfant; A Alam; A Toubert; A Bensussan; P Le Bouteiller Journal: J Immunol Date: 2000-06-15 Impact factor: 5.422
Authors: F A Le Gal; B Riteau; C Sedlik; I Khalil-Daher; C Menier; J Dausset; J G Guillet; E D Carosella; N Rouas-Freiss Journal: Int Immunol Date: 1999-08 Impact factor: 4.823
Authors: Joël LeMaoult; Irène Krawice-Radanne; Jean Dausset; Edgardo D Carosella Journal: Proc Natl Acad Sci U S A Date: 2004-04-21 Impact factor: 11.205
Authors: JoonHo Lee; Roberto Romero; Yi Xu; Jezid Miranda; Wonsuk Yoo; Piya Chaemsaithong; Juan Pedro Kusanovic; Tinnakorn Chaiworapongsa; Adi L Tarca; Steven J Korzeniewski; Sonia S Hassan; Nandor Gabor Than; Bo Hyun Yoon; Chong Jai Kim Journal: Am J Reprod Immunol Date: 2013-08 Impact factor: 3.886