| Literature DB >> 24797563 |
Qunhong Weng1, Binju Wang, Xuebin Wang, Nobutaka Hanagata, Xia Li, Dequan Liu, Xi Wang, Xiangfen Jiang, Yoshio Bando, Dmitri Golberg.
Abstract
Developing materials for "Nano-vehicles" with clinically approved drugs encapsulated is envisaged to enhance drug therapeutic effects and reduce the adverse effects. However, design and preparation of the biomaterials that are porous, nontoxic, soluble, and stable in physiological solutions and could be easily functionalized for effective drug deliveries are still challenging. Here, we report an original and simple thermal substitution method to fabricate perfectly water-soluble and porous boron nitride (BN) materials featuring unprecedentedly high hydroxylation degrees. These hydroxylated BNs are biocompatible and can effectively load anticancer drugs (e.g., doxorubicin, DOX) up to contents three times exceeding their own weight. The same or even fewer drugs that are loaded on such BN carriers exhibit much higher potency for reducing the viability of LNCaP cancer cells than free drugs.Entities:
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Year: 2014 PMID： 24797563 DOI： 10.1021/nn5014808
Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881