Serafim Tsitsilonis1, Panayiotis E Chatzistergos, Chatzistergos E Panayiotis2, Athanasios S Mitousoudis, Mitousoudis S Athanasios2, Stavros K Kourkoulis, Kourkoulis K Stavros2, Ioannis S Vlachos, Vlachos S Ioannis3, George Agrogiannis, Agrogiannis George4, Konstantinos Fasseas, Fasseas Konstantinos5, Despina N Perrea, Perrea N Despina3, Aristides B Zoubos, Zoubos B Aristides6. 1. Laboratory for Experimental Surgery and Surgical Research "N.S. Christeas", Athens Medical School, Agiou Thoma str. 15B, 11527 Athens, Greece; Charité - University Medicine Berlin, Center for Musculoskeletal Surgery, Augustenburger Platz 1, 13353 Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Charité - University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. Electronic address: serafeim.tsitsilonis@charite.de. 2. Unit of Biomechanics, Department of Mechanics, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Zografou Campus, 15773 Athens, Greece. 3. Laboratory for Experimental Surgery and Surgical Research "N.S. Christeas", Athens Medical School, Agiou Thoma str. 15B, 11527 Athens, Greece. 4. Laboratory of Electron Microscopy, Faculty of Agricultural Biotechnology, Department of Plant Biology, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece. 5. 1st Department of Pathology, University of Athens, Athens Medical School, Athens, Greece. 6. Department of Orthopaedic Surgery, University of Athens, Athens Medical School, "Attikon" University Hospital, Rimini str. 1, 12462 Athens, Greece.
Abstract
BACKGROUND: The effect of anabolic androgenic steroids on tendons has not yet been fully elucidated. Aim of the present study was the evaluation of the impact of anabolic androgenic steroids on the biomechanical and histological characteristics of Achilles tendons. METHODS: Twenty-four male Wistar rats were randomized into four groups with exercise and anabolic steroids (nandrolone decanoate) serving as variables. Protocol duration was 12 weeks. Following euthanasia, tendons' biomechanical properties were tested with the use of a modified clamping configuration. Histological examination with light and electron microscopy were also performed. RESULTS: In the group of anabolic steroids and exercise the lowest fracture stress values were observed, while in the exercise group the highest ones. Histological examination by light and electron microscopy revealed areas of collagen dysplasia and an increased epitendon in the groups receiving anabolic steroids and exercise. CONCLUSIONS: These findings suggest that anabolic androgenic steroids reverse the beneficial effect of exercise, thus resulting in inferior maximal stress values.
BACKGROUND: The effect of anabolic androgenic steroids on tendons has not yet been fully elucidated. Aim of the present study was the evaluation of the impact of anabolic androgenic steroids on the biomechanical and histological characteristics of Achilles tendons. METHODS: Twenty-four male Wistar rats were randomized into four groups with exercise and anabolic steroids (nandrolone decanoate) serving as variables. Protocol duration was 12 weeks. Following euthanasia, tendons' biomechanical properties were tested with the use of a modified clamping configuration. Histological examination with light and electron microscopy were also performed. RESULTS: In the group of anabolic steroids and exercise the lowest fracture stress values were observed, while in the exercise group the highest ones. Histological examination by light and electron microscopy revealed areas of collagen dysplasia and an increased epitendon in the groups receiving anabolic steroids and exercise. CONCLUSIONS: These findings suggest that anabolic androgenic steroids reverse the beneficial effect of exercise, thus resulting in inferior maximal stress values.
Authors: Gen Kanayama; James DeLuca; William P Meehan; James I Hudson; Stephanie Isaacs; Aaron Baggish; Rory Weiner; Lyle Micheli; Harrison G Pope Journal: Am J Sports Med Date: 2015-09-11 Impact factor: 6.202
Authors: Nima Gharahdaghi; Supreeth Rudrappa; Matthew S Brook; Wesam Farrash; Iskandar Idris; Muhammad Hariz Abdul Aziz; Fawzi Kadi; Konstantinos Papaioannou; Bethan E Phillips; Tanvir Sian; Philip J Herrod; Daniel J Wilkinson; Nathaniel J Szewczyk; Kenneth Smith; Philip J Atherton Journal: J Cachexia Sarcopenia Muscle Date: 2022-03-01 Impact factor: 12.910