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Literature DB >> 2479550

Post-transcriptional control of negative acute phase genes by transforming growth factor beta.

Abstract

During the acute phase (AP) reaction the expression of a series of liver-specific genes coding for secretory proteins is either stimulated or suppressed by different cytokines released by activated monocytes. Transforming growth factor beta (TGF-beta) is a cytokine that, first identified for its ability to regulate cellular growth, has been gradually recognized to modulate several other functions. We have investigated the effect of TGF-beta on the expression of acute phase genes in liver cells. We found that TGF-beta selectively induces a specific decreases in the amount of mRNAs of genes negatively regulated during AP reaction, like albumin and apolipoprotein A-I (ApoA-I). The inhibitory effect of TGF-beta on the expression of negative AP genes is primarily post-transcriptional and it is very likely to be mediated via an enhancement of the turnover of both albumin and ApoA-I mRNAs.

Entities: Chemical

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Year: 1989 PMID： 2479550 PMCID： PMC402062 DOI： 10.1002/j.1460-2075.1989.tb08553.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

29 in total

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Journal: EMBO J Date: 1989-04 Impact factor: 11.598

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12 in total

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Journal: J Clin Invest Date: 1995-03 Impact factor: 14.808

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Authors: Takahiro Masaki; Tomokazu Matsuura; Kiyoshi Ohkawa; Tatsuo Miyamura; Isao Okazaki; Tetsu Watanabe; Tetsuro Suzuki
Journal: Biochem J Date: 2006-07-15 Impact factor: 3.857

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Journal: Nucleic Acids Res Date: 1993-01-25 Impact factor: 16.971

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Journal: Mol Cell Biol Date: 1992-04 Impact factor: 4.272