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Literature DB >> 24795087

Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes.

Rinke Stienstra¹, Yulia Haim, Yael Riahi, Mihai Netea, Assaf Rudich, Gil Leibowitz.

Abstract

Autophagy is a lysosomal degradation pathway recycling intracellular long-lived proteins and damaged organelles, thereby maintaining cellular homeostasis. In addition to inflammatory processes, autophagy has been implicated in the regulation of adipose tissue and beta cell functions. In obesity and type 2 diabetes autophagic activity is modulated in a tissue-dependent manner. In this review we discuss the regulation of autophagy in adipose tissue and beta cells, exemplifying tissue-specific dysregulation of autophagy and its implications for the pathophysiology of obesity and type 2 diabetes. We will highlight common themes and outstanding gaps in our understanding, which need to be addressed before autophagy could be envisioned as a therapeutic target for the treatment of obesity and diabetes.

Entities: Disease

Mesh：

Year: 2014 PMID： 24795087 DOI： 10.1007/s00125-014-3255-3

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

102 in total

1. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans.

Authors: Saverio Cinti; Grant Mitchell; Giorgio Barbatelli; Incoronata Murano; Enzo Ceresi; Emanuela Faloia; Shupei Wang; Melanie Fortier; Andrew S Greenberg; Martin S Obin
Journal: J Lipid Res Date: 2005-09-08 Impact factor: 5.922

Review 2. Glucolipotoxicity: fuel excess and beta-cell dysfunction.

Authors: Vincent Poitout; R Paul Robertson
Journal: Endocr Rev Date: 2007-11-29 Impact factor: 19.871

Review 3. Autophagy: from phenomenology to molecular understanding in less than a decade.

Authors: Daniel J Klionsky
Journal: Nat Rev Mol Cell Biol Date: 2007-11 Impact factor: 94.444

4. Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation.

Authors: Juan-Carlos Rodríguez-Prados; Paqui G Través; Jimena Cuenca; Daniel Rico; Julián Aragonés; Paloma Martín-Sanz; Marta Cascante; Lisardo Boscá
Journal: J Immunol Date: 2010-05-24 Impact factor: 5.422

5. The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead?

Authors: Y Uchizono; C Alarcón; B L Wicksteed; B J Marsh; C J Rhodes
Journal: Diabetes Obes Metab Date: 2007-11 Impact factor: 6.577

6. Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure.

Authors: Chutima Talchai; Shouhong Xuan; Hua V Lin; Lori Sussel; Domenico Accili
Journal: Cell Date: 2012-09-14 Impact factor: 41.582

7. Identification of a candidate therapeutic autophagy-inducing peptide.

Authors: Sanae Shoji-Kawata; Rhea Sumpter; Matthew Leveno; Grant R Campbell; Zhongju Zou; Lisa Kinch; Angela D Wilkins; Qihua Sun; Kathrin Pallauf; Donna MacDuff; Carlos Huerta; Herbert W Virgin; J Bernd Helms; Ruud Eerland; Sharon A Tooze; Ramnik Xavier; Deborah J Lenschow; Ai Yamamoto; David King; Olivier Lichtarge; Nick V Grishin; Stephen A Spector; Dora V Kaloyanova; Beth Levine
Journal: Nature Date: 2013-01-30 Impact factor: 49.962

8. Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes.

Authors: Etty Bachar-Wikstrom; Jakob D Wikstrom; Yafa Ariav; Boaz Tirosh; Nurit Kaiser; Erol Cerasi; Gil Leibowitz
Journal: Diabetes Date: 2012-12-28 Impact factor: 9.461

Review 9. Mapping autophagy on to your metabolic radar.

Authors: Eijiro Yamada; Rajat Singh
Journal: Diabetes Date: 2012-02 Impact factor: 9.461

10. Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1.

Authors: Etti Bachar; Yafa Ariav; Mali Ketzinel-Gilad; Erol Cerasi; Nurit Kaiser; Gil Leibowitz
Journal: PLoS One Date: 2009-03-23 Impact factor: 3.240

39 in total

1. Oleate disrupts cAMP signaling, contributing to potent stimulation of pancreatic β-cell autophagy.

Authors: Kwan Yi Chu; Liam O'Reilly; Natalie Mellet; Peter J Meikle; Clarissa Bartley; Trevor J Biden
Journal: J Biol Chem Date: 2018-12-05 Impact factor: 5.157

Review 2. Autophagy and Obesity-Related Lung Disease.

Authors: Maria A Pabon; Kevin C Ma; Augustine M K Choi
Journal: Am J Respir Cell Mol Biol Date: 2016-05 Impact factor: 6.914

3. Niemann-Pick type C2 deficiency impairs autophagy-lysosomal activity, mitochondrial function, and TLR signaling in adipocytes.

Authors: Hong Guo; Ming Zhao; Xiaoxue Qiu; Jessica A Deis; Haiyan Huang; Qi-Qun Tang; Xiaoli Chen
Journal: J Lipid Res Date: 2016-07-08 Impact factor: 5.922

4. Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome.

Authors: Hao Wu; You Wang; Wenhui Li; Hui Chen; Lei Du; Dong Liu; Xiaohui Wang; Tao Xu; Lei Liu; Quan Chen
Journal: Autophagy Date: 2019-04-06 Impact factor: 16.016

5. Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes.

Authors: Ting Yuan; Sahar Rafizadeh; Kanaka Durga Devi Gorrepati; Blaz Lupse; Jose Oberholzer; Kathrin Maedler; Amin Ardestani
Journal: Diabetologia Date: 2016-12-21 Impact factor: 10.122

Review 6. Mitochondrial network regulation and its potential interference with inflammatory signals in pancreatic beta cells.

Authors: Simone Baltrusch
Journal: Diabetologia Date: 2016-02-12 Impact factor: 10.122

7. Decreased adiponectin links elevated adipose tissue autophagy with adipocyte endocrine dysfunction in obesity.

Authors: N Slutsky; M Vatarescu; Y Haim; N Goldstein; B Kirshtein; I Harman-Boehm; Y Gepner; I Shai; N Bashan; M Blüher; A Rudich
Journal: Int J Obes (Lond) Date: 2016-01-20 Impact factor: 5.095

8. High-fat diet increases autophagic flux in pancreatic beta cells in vivo and ex vivo in mice.

Authors: Kwan Yi Chu; Liam O'Reilly; Georg Ramm; Trevor J Biden
Journal: Diabetologia Date: 2015-06-14 Impact factor: 10.122

9. Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation.

Authors: Scott Frendo-Cumbo; Javier R Jaldin-Fincati; Etienne Coyaud; Estelle M N Laurent; Logan K Townsend; Joel M J Tan; Ramnik J Xavier; Nicolas J Pillon; Brian Raught; David C Wright; John Hunter Brumell; Amira Klip
Journal: J Biol Chem Date: 2019-09-12 Impact factor: 5.157

Review 10. Regulation of autophagy by mitochondrial phospholipids in health and diseases.

Authors: Paul Hsu; Yuguang Shi
Journal: Biochim Biophys Acta Mol Cell Biol Lipids Date: 2016-08-05 Impact factor: 4.698