Literature DB >> 24794750

Probing linker design in citric acid-ciprofloxacin conjugates.

Stephen J Milner1, Anna M Snelling2, Kevin G Kerr3, Ahmad Abd-El-Aziz4, Gavin H Thomas5, Roderick E Hubbard6, Anne Routledge7, Anne-Kathrin Duhme-Klair8.   

Abstract

A series of structurally related citric acid-ciprofloxacin conjugates was synthesised to investigate the influence of the linker between citric acid and ciprofloxacin on antibacterial activities. Minimum inhibitory concentrations (MICs) were determined against a panel of reference strains and clinical isolates of bacteria associated with infection in humans and correlated with the DNA gyrase inhibitory activity. The observed trend was rationalised by computational modelling.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antibiotic; Citrate; Computational modelling; Siderophore

Mesh：

Substances：

Year:  2014        PMID： 24794750     DOI： 10.1016/j.bmc.2014.04.009

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  8 in total

1.  Esterase-Catalyzed Siderophore Hydrolysis Activates an Enterobactin-Ciprofloxacin Conjugate and Confers Targeted Antibacterial Activity.

Authors:  Wilma Neumann; Martina Sassone-Corsi; Manuela Raffatellu; Elizabeth M Nolan
Journal:  J Am Chem Soc       Date:  2018-04-10       Impact factor: 15.419

2.  Tracking Uptake and Metabolism of Xenometallomycins Using a Multi-Isotope Tagging Strategy.

Authors:  Apurva Pandey; Minhua Cao; Eszter Boros
Journal:  ACS Infect Dis       Date:  2022-03-23       Impact factor: 5.578

3.  Theranostic Gallium Siderophore Ciprofloxacin Conjugate with Broad Spectrum Antibiotic Potency.

Authors:  Apurva Pandey; Chloé Savino; Shin Hye Ahn; Zhaoyong Yang; Steven G Van Lanen; Eszter Boros
Journal:  J Med Chem       Date:  2019-10-17       Impact factor: 7.446

4.  Evaluation of a reducible disulfide linker for siderophore-mediated delivery of antibiotics.

Authors:  Wilma Neumann; Elizabeth M Nolan
Journal:  J Biol Inorg Chem       Date:  2018-07-02       Impact factor: 3.358

Review 5.  Coordination Complexes to Combat Bacterial Infections: Recent Developments, Current Directions and Future Opportunities.

Authors:  Apurva Pandey; Eszter Boros
Journal:  Chemistry       Date:  2021-02-25       Impact factor: 5.020

Review 6.  Modifications of quinolones and fluoroquinolones: hybrid compounds and dual-action molecules.

Authors:  Joanna Fedorowicz; Jarosław Sączewski
Journal:  Monatsh Chem       Date:  2018-06-07       Impact factor: 1.451

Review 7.  Siderophore-Antibiotic Conjugate Design: New Drugs for Bad Bugs?

Authors:  Kokob H Negash; James K S Norris; James T Hodgkinson
Journal:  Molecules       Date:  2019-09-11       Impact factor: 4.411

8.  The intrinsic antimicrobial activity of citric acid-coated manganese ferrite nanoparticles is enhanced after conjugation with the antifungal peptide Cm-p5.

Authors:  Carlos Lopez-Abarrategui; Viviana Figueroa-Espi; Maria B Lugo-Alvarez; Caroline D Pereira; Hilda Garay; João Arg Barbosa; Rosana Falcão; Linnavel Jiménez-Hernández; Osvaldo Estévez-Hernández; Edilso Reguera; Octavio L Franco; Simoni C Dias; Anselmo J Otero-Gonzalez
Journal:  Int J Nanomedicine       Date:  2016-08-09
  8 in total

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