Literature DB >> 2479378

A mitogen for Schwann cells is derived from myelin basic protein.

R R Baichwal1, G H DeVries.   

Abstract

Evidence is presented that a mitogen can be produced from myelin basic protein (MBP) which may be related to the Schwann cell proliferation characteristic of Wallerian degeneration. Myelin derived from the shiverer mutant which is devoid of MBP is also devoid of mitogenic activity. Absorption of the mitogen with a polyclonal antisera to MBP abolishes the mitogenic effect. In addition, only liposomes containing MBP are mitogenic to cultured Schwann cells; liposomes containing other myelin-specific proteins do not stimulate Schwann cell division. These results directly demonstrate the MBP origin of a mitogen for Schwann cells.

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Year:  1989        PMID： 2479378     DOI： 10.1016/0006-291x(89)91541-6

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

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Authors:  S F Tzeng; G E Deibler; G H DeVries
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4.  P0 and myelin basic protein-like immunoreactivities following ligation of the sciatic nerve in the rat.

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Review 5.  Role of Campylobacter jejuni infection in the pathogenesis of Guillain-Barré syndrome: an update.

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6.  The characterisation of Pax3 expressant cells in adult peripheral nerve.

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  6 in total

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