Zhe Shen1, Stefan Munker2, Chenyang Wang3, Lei Xu1, Hua Ye1, Hongtan Chen1, Genyun Xu4, Hong Zhang3, Lihua Chen1, Chaohui Yu1, Youming Li5. 1. Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, China. 2. Molecular Hepatology-Alcohol Associated Diseases, II. Medical Clinic Faculty of Medicine at Mannheim, University of Heidelberg, 68167 Mannheim, Germany. 3. Institute of Biostatistics, School of Life Sciences, Fudan University, 200433 Shanghai, China. 4. Clinical Laboratory, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, China. 5. Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, China. Electronic address: zjulym@126.com.
Abstract
BACKGROUND: Alcohol, overweight, and lipid metabolism contribute to fatty liver and atherosclerosis pathogenesis. OBJECTIVE: To study the association of alcoholic intake, overweight, and dyslipidemia. METHODS: We randomly selected 482 age- and sex-matched individuals from East China. Gender, age, education level, smoking, hypertension, daily alcohol intake, drinking duration, and body mass index (BMI) were evaluated in association with triglyceride, total cholesterol, high-density (HDL-C), and low-density lipoprotein-cholesterol. RESULTS: The association between dyslipidemia and 8 predictors of disease was made by regression analysis through the generalized additive model. The results showed that age, daily alcohol intake, and BMI were all closely associated with hypertriglyceridemia. Age, duration of drinking, and BMI were all closely associated with hypercholesterolemia. Age and BMI status were both closely associated with high LDL-C levels. By contrast, none of the 8 predictors was closely associated with low HDL-C levels (all P < .05). CONCLUSIONS: Daily alcohol intake was a risk factor for hypertriglyceridemia. By contrast, drinking duration was a protective factor against hypercholesterolemia. Age and BMI were important risk factors for dyslipidemia (excluding HDL-C).
BACKGROUND:Alcohol, overweight, and lipid metabolism contribute to fatty liver and atherosclerosis pathogenesis. OBJECTIVE: To study the association of alcoholic intake, overweight, and dyslipidemia. METHODS: We randomly selected 482 age- and sex-matched individuals from East China. Gender, age, education level, smoking, hypertension, daily alcohol intake, drinking duration, and body mass index (BMI) were evaluated in association with triglyceride, total cholesterol, high-density (HDL-C), and low-density lipoprotein-cholesterol. RESULTS: The association between dyslipidemia and 8 predictors of disease was made by regression analysis through the generalized additive model. The results showed that age, daily alcohol intake, and BMI were all closely associated with hypertriglyceridemia. Age, duration of drinking, and BMI were all closely associated with hypercholesterolemia. Age and BMI status were both closely associated with high LDL-C levels. By contrast, none of the 8 predictors was closely associated with low HDL-C levels (all P < .05). CONCLUSIONS: Daily alcohol intake was a risk factor for hypertriglyceridemia. By contrast, drinking duration was a protective factor against hypercholesterolemia. Age and BMI were important risk factors for dyslipidemia (excluding HDL-C).
Authors: Alan J Mouton; John K Maxi; Flavia Souza-Smith; Gregory J Bagby; Nicholas W Gilpin; Patricia E Molina; Jason D Gardner Journal: Alcohol Clin Exp Res Date: 2016-07-04 Impact factor: 3.455