Literature DB >> 24792720

Huntington's disease: from disease mechanisms to therapies.

Craig Blackstone1.   

Abstract

Entities:  

Mesh：

Year:  2014        PMID： 24792720      PMCID： PMC4083760          DOI： 10.1016/j.drudis.2014.04.013

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


× No keyword cloud information.
  9 in total

Review 1.  Transcriptional dysregulation in Huntington's disease.

Authors:  J H Cha
Journal:  Trends Neurosci       Date:  2000-09       Impact factor: 13.837

2.  Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea.

Authors:  J T Coyle; R Schwarcz
Journal:  Nature       Date:  1976-09-16       Impact factor: 49.962

Review 3.  Increased mitochondrial fission and neuronal dysfunction in Huntington's disease: implications for molecular inhibitors of excessive mitochondrial fission.

Authors:  P Hemachandra Reddy
Journal:  Drug Discov Today       Date:  2014-03-28       Impact factor: 7.851

Review 4.  Huntington's Disease.

Authors:  Steven Finkbeiner
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-06-01       Impact factor: 10.005

Review 5.  Mechanisms of synaptic dysfunction and excitotoxicity in Huntington's disease.

Authors:  Marja D Sepers; Lynn A Raymond
Journal:  Drug Discov Today       Date:  2014-03-03       Impact factor: 7.851

6.  Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.

Authors:  L Mangiarini; K Sathasivam; M Seller; B Cozens; A Harper; C Hetherington; M Lawton; Y Trottier; H Lehrach; S W Davies; G P Bates
Journal:  Cell       Date:  1996-11-01       Impact factor: 41.582

7.  A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

Authors: 
Journal:  Cell       Date:  1993-03-26       Impact factor: 41.582

8.  Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.

Authors:  S W Davies; M Turmaine; B A Cozens; M DiFiglia; A H Sharp; C A Ross; E Scherzinger; E E Wanker; L Mangiarini; G P Bates
Journal:  Cell       Date:  1997-08-08       Impact factor: 41.582

Review 9.  Transcriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasis.

Authors:  Amit Kumar; Manisha Vaish; Rajiv R Ratan
Journal:  Drug Discov Today       Date:  2014-03-21       Impact factor: 7.851
  9 in total
  4 in total

1.  Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease.

Authors:  José R Naranjo; Hongyu Zhang; Diego Villar; Paz González; Xose M Dopazo; Javier Morón-Oset; Elena Higueras; Juan C Oliveros; María D Arrabal; Angela Prieto; Pilar Cercós; Teresa González; Alicia De la Cruz; Juan Casado-Vela; Alberto Rábano; Carmen Valenzuela; Marta Gutierrez-Rodriguez; Jia-Yi Li; Britt Mellström
Journal:  J Clin Invest       Date:  2016-01-11       Impact factor: 14.808

2.  Targeting the neuronal calcium sensor DREAM with small-molecules for Huntington's disease treatment.

Authors:  Alejandro Lopez-Hurtado; Diego A Peraza; Pilar Cercos; Laura Lagartera; Paz Gonzalez; Xose M Dopazo; Rosario Herranz; Teresa Gonzalez; Mercedes Martin-Martinez; Britt Mellström; Jose R Naranjo; Carmen Valenzuela; Marta Gutierrez-Rodriguez
Journal:  Sci Rep       Date:  2019-05-13       Impact factor: 4.379

3.  Distinct subcellular autophagy impairments in induced neurons from patients with Huntington's disease.

Authors:  Karolina Pircs; Janelle Drouin-Ouellet; Vivien Horváth; Jeovanis Gil; Melinda Rezeli; Raquel Garza; Daniela A Grassi; Yogita Sharma; Isabelle St-Amour; Kate Harris; Marie E Jönsson; Pia A Johansson; Romina Vuono; Shaline V Fazal; Thomas Stoker; Bob A Hersbach; Kritika Sharma; Jessica Lagerwall; Stina Lagerström; Petter Storm; Sébastien S Hébert; György Marko-Varga; Malin Parmar; Roger A Barker; Johan Jakobsson
Journal:  Brain       Date:  2022-09-14       Impact factor: 15.255

4.  Impact of differential and time-dependent autophagy activation on therapeutic efficacy in a model of Huntington disease.

Authors:  Per Ludvik Brattås; Bob A Hersbach; Sofia Madsen; Rebecca Petri; Johan Jakobsson; Karolina Pircs
Journal:  Autophagy       Date:  2020-05-06       Impact factor: 16.016
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.