Shaneda Warren Andersen1, Amy Trentham-Dietz2, Ronald E Gangnon3, John M Hampton4, Jonine D Figueroa5, Halcyon G Skinner3, Corinne D Engelman3, Barbara E Klein6, Linda J Titus7, Kathleen M Egan8, Polly A Newcomb9. 1. University of Wisconsin Carbone Cancer Center, Madison; Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison. Electronic address: snandersen@uwalumni.com. 2. University of Wisconsin Carbone Cancer Center, Madison; Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison. 3. Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison. 4. University of Wisconsin Carbone Cancer Center, Madison. 5. Division of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, MD. 6. Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison. 7. Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH. 8. Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL. 9. University of Wisconsin Carbone Cancer Center, Madison; Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA.
Abstract
PURPOSE: The reproductive windows between age at menarche and age at first birth (standardized age at first birth) and from menarche to menopause (reproductive lifespan) may interact with genetic variants in association with breast cancer risk. METHODS: We assessed this hypothesis in 6131 breast cancer cases and 7274 controls who participated in the population-based Collaborative Breast Cancer Study. Risk factor information was collected through telephone interviews, and DNA samples were collected on a subsample (N= 1484 cases, 1307 controls) to genotype for 13 genome-wide association study-identified loci. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated, and P values for the interaction between reproductive windows and genotypes were obtained by adding cross-product terms to statistical models. RESULTS: For standardized age at first birth, the OR was 1.52 (CI, 1.36-1.71) comparing the highest quintile with the lowest quintile. Carrier status for rs10941679 (5p12) and rs10483813 (RAD51B) appeared to modify this relationship (P = .04 and P = .02, respectively). For reproductive lifespan, the OR comparing the highest quintile with the lowest quintiles was 1.62 (CI, 1.35-1.95). No interactions were detected between genotype and reproductive lifespan (all P > .05). All results were similar regardless of ductal versus lobular breast cancer subtype. CONCLUSIONS: Our results suggest that the reproductive windows are associated with breast cancer risk and that associations may vary by genetic variants.
PURPOSE: The reproductive windows between age at menarche and age at first birth (standardized age at first birth) and from menarche to menopause (reproductive lifespan) may interact with genetic variants in association with breast cancer risk. METHODS: We assessed this hypothesis in 6131 breast cancer cases and 7274 controls who participated in the population-based Collaborative Breast Cancer Study. Risk factor information was collected through telephone interviews, and DNA samples were collected on a subsample (N= 1484 cases, 1307 controls) to genotype for 13 genome-wide association study-identified loci. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated, and P values for the interaction between reproductive windows and genotypes were obtained by adding cross-product terms to statistical models. RESULTS: For standardized age at first birth, the OR was 1.52 (CI, 1.36-1.71) comparing the highest quintile with the lowest quintile. Carrier status for rs10941679 (5p12) and rs10483813 (RAD51B) appeared to modify this relationship (P = .04 and P = .02, respectively). For reproductive lifespan, the OR comparing the highest quintile with the lowest quintiles was 1.62 (CI, 1.35-1.95). No interactions were detected between genotype and reproductive lifespan (all P > .05). All results were similar regardless of ductal versus lobular breast cancer subtype. CONCLUSIONS: Our results suggest that the reproductive windows are associated with breast cancer risk and that associations may vary by genetic variants.
Authors: Daniele Campa; Rudolf Kaaks; Loïc Le Marchand; Christopher A Haiman; Ruth C Travis; Christine D Berg; Julie E Buring; Stephen J Chanock; W Ryan Diver; Lucie Dostal; Agnes Fournier; Susan E Hankinson; Brian E Henderson; Robert N Hoover; Claudine Isaacs; Mattias Johansson; Laurence N Kolonel; Peter Kraft; I-Min Lee; Catherine A McCarty; Kim Overvad; Salvatore Panico; Petra H M Peeters; Elio Riboli; Maria José Sanchez; Fredrick R Schumacher; Guri Skeie; Daniel O Stram; Michael J Thun; Dimitrios Trichopoulos; Shumin Zhang; Regina G Ziegler; David J Hunter; Sara Lindström; Federico Canzian Journal: J Natl Cancer Inst Date: 2011-07-26 Impact factor: 13.506
Authors: Simon N Stacey; Andrei Manolescu; Patrick Sulem; Steinunn Thorlacius; Sigurjon A Gudjonsson; Gudbjörn F Jonsson; Margret Jakobsdottir; Jon T Bergthorsson; Julius Gudmundsson; Katja K Aben; Luc J Strobbe; Dorine W Swinkels; K C Anton van Engelenburg; Brian E Henderson; Laurence N Kolonel; Loic Le Marchand; Esther Millastre; Raquel Andres; Berta Saez; Julio Lambea; Javier Godino; Eduardo Polo; Alejandro Tres; Simone Picelli; Johanna Rantala; Sara Margolin; Thorvaldur Jonsson; Helgi Sigurdsson; Thora Jonsdottir; Jon Hrafnkelsson; Jakob Johannsson; Thorarinn Sveinsson; Gardar Myrdal; Hlynur Niels Grimsson; Steinunn G Sveinsdottir; Kristin Alexiusdottir; Jona Saemundsdottir; Asgeir Sigurdsson; Jelena Kostic; Larus Gudmundsson; Kristleifur Kristjansson; Gisli Masson; James D Fackenthal; Clement Adebamowo; Temidayo Ogundiran; Olufunmilayo I Olopade; Christopher A Haiman; Annika Lindblom; Jose I Mayordomo; Lambertus A Kiemeney; Jeffrey R Gulcher; Thorunn Rafnar; Unnur Thorsteinsdottir; Oskar T Johannsson; Augustine Kong; Kari Stefansson Journal: Nat Genet Date: 2008-04-27 Impact factor: 38.330
Authors: Susan Y Euling; Marcia E Herman-Giddens; Peter A Lee; Sherry G Selevan; Anders Juul; Thorkild I A Sørensen; Leo Dunkel; John H Himes; Grete Teilmann; Shanna H Swan Journal: Pediatrics Date: 2008-02 Impact factor: 7.124
Authors: Gilles Thomas; Kevin B Jacobs; Peter Kraft; Meredith Yeager; Sholom Wacholder; David G Cox; Susan E Hankinson; Amy Hutchinson; Zhaoming Wang; Kai Yu; Nilanjan Chatterjee; Montserrat Garcia-Closas; Jesus Gonzalez-Bosquet; Ludmila Prokunina-Olsson; Nick Orr; Walter C Willett; Graham A Colditz; Regina G Ziegler; Christine D Berg; Saundra S Buys; Catherine A McCarty; Heather Spencer Feigelson; Eugenia E Calle; Michael J Thun; Ryan Diver; Ross Prentice; Rebecca Jackson; Charles Kooperberg; Rowan Chlebowski; Jolanta Lissowska; Beata Peplonska; Louise A Brinton; Alice Sigurdson; Michele Doody; Parveen Bhatti; Bruce H Alexander; Julie Buring; I-Min Lee; Lars J Vatten; Kristian Hveem; Merethe Kumle; Richard B Hayes; Margaret Tucker; Daniela S Gerhard; Joseph F Fraumeni; Robert N Hoover; Stephen J Chanock; David J Hunter Journal: Nat Genet Date: 2009-03-29 Impact factor: 38.330
Authors: Roger L Milne; Ellen L Goode; Montserrat García-Closas; Fergus J Couch; Gianluca Severi; Rebecca Hein; Zachary Fredericksen; Núria Malats; M Pilar Zamora; Jose Ignacio Arias Pérez; Javier Benítez; Thilo Dörk; Peter Schürmann; Johann H Karstens; Peter Hillemanns; Angela Cox; Ian W Brock; Graeme Elliot; Simon S Cross; Sheila Seal; Clare Turnbull; Anthony Renwick; Nazneen Rahman; Chen-Yang Shen; Jyh-Cherng Yu; Chiun-Sheng Huang; Ming-Feng Hou; Børge G Nordestgaard; Stig E Bojesen; Charlotte Lanng; Grethe Grenaker Alnæs; Vessela Kristensen; Anne-Lise Børrensen-Dale; John L Hopper; Gillian S Dite; Carmel Apicella; Melissa C Southey; Diether Lambrechts; Betül T Yesilyurt; Giuseppe Floris; Karin Leunen; Suleeporn Sangrajrang; Valerie Gaborieau; Paul Brennan; James McKay; Jenny Chang-Claude; Shan Wang-Gohrke; Paolo Radice; Paolo Peterlongo; Siranoush Manoukian; Monica Barile; Graham G Giles; Laura Baglietto; Esther M John; Alexander Miron; Stephen J Chanock; Jolanta Lissowska; Mark E Sherman; Jonine D Figueroa; Natalia V Bogdanova; Natalia N Antonenkova; Iosif V Zalutsky; Yuri I Rogov; Peter A Fasching; Christian M Bayer; Arif B Ekici; Matthias W Beckmann; Hermann Brenner; Heiko Müller; Volker Arndt; Christa Stegmaier; Irene L Andrulis; Julia A Knight; Gord Glendon; Anna Marie Mulligan; Arto Mannermaa; Vesa Kataja; Veli-Matti Kosma; Jaana M Hartikainen; Alfons Meindl; Joerg Heil; Claus R Bartram; Rita K Schmutzler; Gilles D Thomas; Robert N Hoover; Olivia Fletcher; Lorna J Gibson; Isabel dos Santos Silva; Julian Peto; Stefan Nickels; Dieter Flesch-Janys; Hoda Anton-Culver; Argyrios Ziogas; Elinor Sawyer; Ian Tomlinson; Michael Kerin; Nicola Miller; Marjanka K Schmidt; Annegien Broeks; Laura J Van 't Veer; Rob A E M Tollenaar; Paul D P Pharoah; Alison M Dunning; Karen A Pooley; Frederik Marme; Andreas Schneeweiss; Christof Sohn; Barbara Burwinkel; Anna Jakubowska; Jan Lubinski; Katarzyna Jaworska; Katarzyna Durda; Daehee Kang; Keun-Young Yoo; Dong-Young Noh; Sei-Hyun Ahn; David J Hunter; Susan E Hankinson; Peter Kraft; Sara Lindstrom; Xiaoqing Chen; Jonathan Beesley; Ute Hamann; Volker Harth; Christina Justenhoven; Robert Winqvist; Katri Pylkäs; Arja Jukkola-Vuorinen; Mervi Grip; Maartje Hooning; Antoinette Hollestelle; Rogier A Oldenburg; Madeleine Tilanus-Linthorst; Elza Khusnutdinova; Marina Bermisheva; Darya Prokofieva; Albina Farahtdinova; Janet E Olson; Xianshu Wang; Manjeet K Humphreys; Qin Wang; Georgia Chenevix-Trench; Douglas F Easton Journal: Cancer Epidemiol Biomarkers Prev Date: 2011-07-27 Impact factor: 4.254
Authors: Roger L Milne; Mia M Gaudet; Amanda B Spurdle; Peter A Fasching; Fergus J Couch; Javier Benítez; José Ignacio Arias Pérez; M Pilar Zamora; Núria Malats; Isabel Dos Santos Silva; Lorna J Gibson; Olivia Fletcher; Nichola Johnson; Hoda Anton-Culver; Argyrios Ziogas; Jonine Figueroa; Louise Brinton; Mark E Sherman; Jolanta Lissowska; John L Hopper; Gillian S Dite; Carmel Apicella; Melissa C Southey; Alice J Sigurdson; Martha S Linet; Sara J Schonfeld; D Michal Freedman; Arto Mannermaa; Veli-Matti Kosma; Vesa Kataja; Päivi Auvinen; Irene L Andrulis; Gord Glendon; Julia A Knight; Nayana Weerasooriya; Angela Cox; Malcolm Wr Reed; Simon S Cross; Alison M Dunning; Shahana Ahmed; Mitul Shah; Hiltrud Brauch; Yon-Dschun Ko; Thomas Brüning; Diether Lambrechts; Joke Reumers; Ann Smeets; Shan Wang-Gohrke; Per Hall; Kamila Czene; Jianjun Liu; Astrid K Irwanto; Georgia Chenevix-Trench; Helene Holland; Graham G Giles; Laura Baglietto; Gianluca Severi; Stig E Bojensen; Børge G Nordestgaard; Henrik Flyger; Esther M John; Dee W West; Alice S Whittemore; Celine Vachon; Janet E Olson; Zachary Fredericksen; Matthew Kosel; Rebecca Hein; Alina Vrieling; Dieter Flesch-Janys; Judith Heinz; Matthias W Beckmann; Katharina Heusinger; Arif B Ekici; Lothar Haeberle; Manjeet K Humphreys; Jonathan Morrison; Doug F Easton; Paul D Pharoah; Montserrat García-Closas; Ellen L Goode; Jenny Chang-Claude Journal: Breast Cancer Res Date: 2010-12-31 Impact factor: 6.466
Authors: Shahana Ahmed; Gilles Thomas; Maya Ghoussaini; Catherine S Healey; Manjeet K Humphreys; Radka Platte; Jonathan Morrison; Melanie Maranian; Karen A Pooley; Robert Luben; Diana Eccles; D Gareth Evans; Olivia Fletcher; Nichola Johnson; Isabel dos Santos Silva; Julian Peto; Michael R Stratton; Nazneen Rahman; Kevin Jacobs; Ross Prentice; Garnet L Anderson; Aleksandar Rajkovic; J David Curb; Regina G Ziegler; Christine D Berg; Saundra S Buys; Catherine A McCarty; Heather Spencer Feigelson; Eugenia E Calle; Michael J Thun; W Ryan Diver; Stig Bojesen; Børge G Nordestgaard; Henrik Flyger; Thilo Dörk; Peter Schürmann; Peter Hillemanns; Johann H Karstens; Natalia V Bogdanova; Natalia N Antonenkova; Iosif V Zalutsky; Marina Bermisheva; Sardana Fedorova; Elza Khusnutdinova; Daehee Kang; Keun-Young Yoo; Dong Young Noh; Sei-Hyun Ahn; Peter Devilee; Christi J van Asperen; R A E M Tollenaar; Caroline Seynaeve; Montserrat Garcia-Closas; Jolanta Lissowska; Louise Brinton; Beata Peplonska; Heli Nevanlinna; Tuomas Heikkinen; Kristiina Aittomäki; Carl Blomqvist; John L Hopper; Melissa C Southey; Letitia Smith; Amanda B Spurdle; Marjanka K Schmidt; Annegien Broeks; Richard R van Hien; Sten Cornelissen; Roger L Milne; Gloria Ribas; Anna González-Neira; Javier Benitez; Rita K Schmutzler; Barbara Burwinkel; Claus R Bartram; Alfons Meindl; Hiltrud Brauch; Christina Justenhoven; Ute Hamann; Jenny Chang-Claude; Rebecca Hein; Shan Wang-Gohrke; Annika Lindblom; Sara Margolin; Arto Mannermaa; Veli-Matti Kosma; Vesa Kataja; Janet E Olson; Xianshu Wang; Zachary Fredericksen; Graham G Giles; Gianluca Severi; Laura Baglietto; Dallas R English; Susan E Hankinson; David G Cox; Peter Kraft; Lars J Vatten; Kristian Hveem; Merethe Kumle; Alice Sigurdson; Michele Doody; Parveen Bhatti; Bruce H Alexander; Maartje J Hooning; Ans M W van den Ouweland; Rogier A Oldenburg; Mieke Schutte; Per Hall; Kamila Czene; Jianjun Liu; Yuqing Li; Angela Cox; Graeme Elliott; Ian Brock; Malcolm W R Reed; Chen-Yang Shen; Jyh-Cherng Yu; Giu-Cheng Hsu; Shou-Tung Chen; Hoda Anton-Culver; Argyrios Ziogas; Irene L Andrulis; Julia A Knight; Jonathan Beesley; Ellen L Goode; Fergus Couch; Georgia Chenevix-Trench; Robert N Hoover; Bruce A J Ponder; David J Hunter; Paul D P Pharoah; Alison M Dunning; Stephen J Chanock; Douglas F Easton Journal: Nat Genet Date: 2009-03-29 Impact factor: 38.330
Authors: Avonne E Connor; Richard N Baumgartner; Kathy B Baumgartner; Christina M Pinkston; Stephanie D Boone; Esther M John; Gabriela Torres-Mejía; Lisa M Hines; Anna R Giuliano; Roger K Wolff; Martha L Slattery Journal: Mol Carcinog Date: 2014-10-22 Impact factor: 4.784
Authors: Peter M Scarbrough; Rachel Palmieri Weber; Edwin S Iversen; Yonathan Brhane; Christopher I Amos; Peter Kraft; Rayjean J Hung; Thomas A Sellers; John S Witte; Paul Pharoah; Brian E Henderson; Stephen B Gruber; David J Hunter; Judy E Garber; Amit D Joshi; Kevin McDonnell; Doug F Easton; Ros Eeles; Zsofia Kote-Jarai; Kenneth Muir; Jennifer A Doherty; Joellen M Schildkraut Journal: Cancer Epidemiol Biomarkers Prev Date: 2015-12-04 Impact factor: 4.254