Literature DB >> 24792462

Vascular effects of diphenylmethoxypiperidine-derived dopamine uptake inhibitors.

Victor M Pulgar1, Jill Keith Harp2.   

Abstract

Vascular effects of 4-aryl methoxypiperidinol compounds previously shown to share with cocaine the ability to inhibit the dopamine transporter are described. All the compounds tested inhibit KCl-induced and noradrenaline-dependent contractions in mesenteric arteries ex vivo. Thus, diphenylpyraline and its analogs may have a role as therapeutic options for the treatment of some of the cardiotoxic effects of cocaine intoxications.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Arterial contraction; Dopamine transporter; Piperidinol-4

Mesh：

Substances：

Year:  2014        PMID： 24792462      PMCID： PMC4056188          DOI： 10.1016/j.bmcl.2014.04.040

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  26 in total

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Authors:  R Leurs; M K Church; M Taglialatela
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3.  Acute cocaine results in rapid rises in intracellular free calcium concentration in canine cerebral vascular smooth muscle cells: possible relation to etiology of stroke.

Authors:  A Zhang; T P Cheng; B T Altura; B M Altura
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Review 4.  Effects of cocaine on the coronary arteries.

Authors:  B S Benzaquen; V Cohen; M J Eisenberg
Journal:  Am Heart J       Date:  2001-09       Impact factor: 4.749

5.  The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines.

Authors:  Gennady B Lapa; Gary D Byrd; Alla A Lapa; Evgeny A Budygin; Steven R Childers; Sara R Jones; Jill J Harp
Journal:  Bioorg Med Chem Lett       Date:  2005-11-15       Impact factor: 2.823

6.  Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties.

Authors:  Gennady B Lapa; Tiffany A Mathews; Jill Harp; Evgeny A Budygin; Sara R Jones
Journal:  Eur J Pharmacol       Date:  2004-12-08       Impact factor: 4.432

7.  Unusual effects of histamine antagonists on canine nasal blood vessels.

Authors:  K Ichimura; R T Jackson
Journal:  Ann Otol Rhinol Laryngol       Date:  1985 May-Jun       Impact factor: 1.547

Review 8.  Crack whips the heart: a review of the cardiovascular toxicity of cocaine.

Authors:  Luis Afonso; Tamam Mohammad; Deepak Thatai
Journal:  Am J Cardiol       Date:  2007-08-13       Impact factor: 2.778

9.  Structure-activity relationships of astemizole derivatives for inhibition of store operated Ca2+ channels and exocytosis.

Authors:  M J Fischer; J J Paulussen; J P Tollenaere; N J De Mol; L H Janssen
Journal:  Eur J Pharmacol       Date:  1998-06-05       Impact factor: 4.432

10.  Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters.

Authors:  Manoj Mishra; Rohit Kolhatkar; Juan Zhen; Ingrid Parrington; Maarten E A Reith; Aloke K Dutta
Journal:  Bioorg Med Chem       Date:  2008-01-11       Impact factor: 3.641
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