A Chebbi1, H Bouguila2, S Boussaid2, N Ben Aleya2, H Zgholi2, I Malek2, I Zeghal2, L Nacef2. 1. Department A of ophthalmology, Hedi Rais institute of ophthalmology, boulevard 9-Avril, 1006 Bab Saadoun, Tunis, Tunisie. Electronic address: amel.chenaoui@yahoo.fr. 2. Department A of ophthalmology, Hedi Rais institute of ophthalmology, boulevard 9-Avril, 1006 Bab Saadoun, Tunis, Tunisie.
Abstract
PURPOSE: To report the relative frequency of presenting signs in Tunisian children with retinoblastoma and to evaluate their prognostic impact. METHODS: A retrospective study was undertaken of 200 patients with retinoblastoma examined and treated between January 1993 and June 2009. RESULTS: There were 123 boys and 77 girls. For all cases, mean age at diagnosis was 29.8 months (range, 1 month to 9 years). There were 138 (69%) unilateral cases and 62 (31%) bilateral cases. Nineteen children (9.5%) had a family history of retinoblastoma. The most common signs were leukocoria (80%) and strabismus (28%) followed by proptosis. Orbital inflammation, hyphemia and phthisis are rare presenting findings in retinoblastoma. In our series, 26 children (13%) presented with extraocular retinoblastoma. Leukocoria and proptosis are significantly associated with a worse prognosis. CONCLUSION: The ability to recognize the presenting signs and symptoms of retinoblastoma can lead to earlier diagnosis and better prognosis.
PURPOSE: To report the relative frequency of presenting signs in Tunisian children with retinoblastoma and to evaluate their prognostic impact. METHODS: A retrospective study was undertaken of 200 patients with retinoblastoma examined and treated between January 1993 and June 2009. RESULTS: There were 123 boys and 77 girls. For all cases, mean age at diagnosis was 29.8 months (range, 1 month to 9 years). There were 138 (69%) unilateral cases and 62 (31%) bilateral cases. Nineteen children (9.5%) had a family history of retinoblastoma. The most common signs were leukocoria (80%) and strabismus (28%) followed by proptosis. Orbital inflammation, hyphemia and phthisis are rare presenting findings in retinoblastoma. In our series, 26 children (13%) presented with extraocular retinoblastoma. Leukocoria and proptosis are significantly associated with a worse prognosis. CONCLUSION: The ability to recognize the presenting signs and symptoms of retinoblastoma can lead to earlier diagnosis and better prognosis.
Authors: Robert M Lukamba; Jean-Jacques A Yao; Theophile A Kabesha; Aleine N Budiongo; Ben B Monga; Albert T Mwembo; Pierre Bey; Gabrielle B Chenge; Laurence Desjardins; Oscar N Luboya; François Doz; Cristina D Stefan Journal: J Glob Oncol Date: 2018-09