Literature DB >> 24792225

An efficient tandem approach for the synthesis of functionalized 2-pyridone-3-carboxylic acids using three-component reaction in aqueous media.

Saber Mehrparvar1, Saeed Balalaie, Mahnaz Rabbanizadeh, Elmira Ghabraie, Frank Rominger.   

Abstract

Novel analogs of 2-pyridone-3-carboxylic acids 4a-l have been prepared by the three-component reaction of 3-formyl chromone, Meldrum's acid, and primary amines in the presence of a catalytic amount of diammonium hydrogen phosphate in water. Good-to-high yields, easy work-up, and an environmentally friendly profile are the advantages of this method for the synthesis of 2-pyridone-3-carboxylic acid derivatives.

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Year:  2014        PMID： 24792225     DOI： 10.1007/s11030-014-9522-x

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  25 in total

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2.  N-Methyl-4-hydroxy-2-pyridinone analogues from Fusarium oxysporum.

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3.  Attenuation of cardiac fibrosis by pirfenidone and amiloride in DOCA-salt hypertensive rats.

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Journal:  Br J Pharmacol       Date:  2002-02       Impact factor: 8.739

Review 4.  The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors.

Authors:  Q Li; L A Mitscher; L L Shen
Journal:  Med Res Rev       Date:  2000-07       Impact factor: 12.944

5.  Highly efficient and mild copper-catalyzed N- and C-arylations with aryl bromides and iodides.

Authors:  Henri-Jean Cristau; Pascal P Cellier; Jean-Francis Spindler; Marc Taillefer
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6.  An efficient and facile synthesis of 3-amino-5-chromenyl-butenolides from 3-formyl chromone, dialkyl acetylenedicarboxylate, and primary amines.

Authors:  Saeed Balalaie; Morteza Ashouriha; Frank Rominger; Hamid Reza Bijanzadeh
Journal:  Mol Divers       Date:  2013-01-23       Impact factor: 2.943

7.  Vilsmeier-Haack reactions of 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans toward the synthesis of highly substituted pyridin-2(1H)-ones.

Authors:  Dexuan Xiang; Yang Yang; Rui Zhang; Yongjiu Liang; Wei Pan; Jie Huang; Dewen Dong
Journal:  J Org Chem       Date:  2007-10-04       Impact factor: 4.354

8.  Domino reaction of alpha-acetyl-alpha-carbamoyl ketene dithioacetals with Vilsmeier reagents: a novel and efficient synthesis of 4-halogenated 2(1H)-pyridinones.

Authors:  Li Chen; Yu-Long Zhao; Qun Liu; Chao Cheng; Cheng-Ri Piao
Journal:  J Org Chem       Date:  2007-11-02       Impact factor: 4.354

9.  Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Authors:  Y H Hsiang; R Hertzberg; S Hecht; L F Liu
Journal:  J Biol Chem       Date:  1985-11-25       Impact factor: 5.157

10.  Efficient one-pot synthesis of highly substituted pyridin-2(1H)-ones via the Vilsmeier-Haack reaction of 1-acetyl,1-carbamoyl cyclopropanes.

Authors:  Wei Pan; Dewen Dong; Kewei Wang; Jie Zhang; Rigenhada Wu; Dexuan Xiang; Qun Liu
Journal:  Org Lett       Date:  2007-05-16       Impact factor: 6.005
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  2 in total

1.  A one-pot three-component reaction involving 2-aminochromone in aqueous micellar medium: a green synthesis of hexahydrochromeno[2,3-b]quinolinedione.

Authors:  Jaydip Ghosh; Pritam Biswas; Michael G B Drew; Chandrakanta Bandyopadhyay
Journal:  Mol Divers       Date:  2015-03-11       Impact factor: 2.943

2.  Synthesis and Decarboxylation of Functionalized 2-Pyridone-3-carboxylic Acids and Evaluation of their Antimicrobial Activity and Molecular Docking.

Authors:  Elmira Meghrazi Ahadi; Homa Azizian; Vaezeh Fathi Vavsari; Atousa Aliahmadi; Zeinab Shahsavari; Hamid R Bijanzadeh; Saeed Balalaie
Journal:  Iran J Pharm Res       Date:  2021       Impact factor: 1.696
  2 in total

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