Roser Ferrer1, Eva Pardina2, Joana Rossell2, Juan Antonio Baena-Fustegueras3, Albert Lecube4, José María Balibrea5, Enric Caubet5, Oscar González5, Ramón Vilallonga5, Jose Manuel Fort5, Julia Peinado-Onsurbe6. 1. Biochemistry Department, Hospital Universitari Vall D'Hebron, Universitat Autònoma De Barcelona, Spain. 2. Biochemistry and Molecular Biology Department, Biology Faculty, Barcelona University, Diagonal 643, 08028 Barcelona, Spain. 3. Arnau de Vilanova University Hospital (UdL), Surgery Unit, Spain. 4. Endocrinology and Nutrition Department at Arnau de Vilanova University Hospital (UdL) and Diabetes and Metabolism Research Unit (VHIR, UAB) and CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM) at the Instituto de Salud Carlos III, Spain. 5. Endocrinology Surgery Unit, Hospital Universitari Vall D'Hebron, Universitat Autònoma De Barcelona, Spain. 6. Biochemistry and Molecular Biology Department, Biology Faculty, Barcelona University, Diagonal 643, 08028 Barcelona, Spain. Electronic address: jpeinado@ub.edu.
Abstract
BACKGROUND & AIMS: We have investigated the differences in plasma parameters and serum trace elements between "healthy" and unhealthy morbidly obese patients before and after Roux-en-Y gastric bypass surgery. METHODS: A group of 32 morbidly obese patients undergoing bariatric surgery were divided into three groups. Group 1 subjects were free of dyslipidemia and type II diabetes mellitus (defined as "healthy" obese, DM-DL-); Group 2 subjects had only the presence of dyslipidemia (DM-DL+), while group 3 patients demonstrated the presence of both (DM + DL+). In all patients, we studied haematological, haemostasis, anaemia, coagulation plasma and trace elements parameters before and 1, 6 and 12 months after gastric bypass surgery. RESULTS: We found significant differences in some haematological parameters, including haemostasis (e.g., T-Quick, p = 0.0048) and coagulation (e.g., ATIII and PAI-1, p = 0.001 and p < 0.0001, respectively) and in anaemia parameters (e.g., folate, cobalamin and transferrin, p = 0.0002, p < 0.0001 and p = 0.0001, respectively) but also in serum trace elements between the groups. However, the response to bariatric surgery was similar in the three groups. CONCLUSION: Any healthy morbid obese subject is really metabolically "unhealthy" because he or she has many other haematologic or serum abnormalities that are often not included in the criteria for the definition of "healthy" in these obese subjects.
BACKGROUND & AIMS: We have investigated the differences in plasma parameters and serum trace elements between "healthy" and unhealthy morbidly obesepatients before and after Roux-en-Y gastric bypass surgery. METHODS: A group of 32 morbidly obesepatients undergoing bariatric surgery were divided into three groups. Group 1 subjects were free of dyslipidemia and type II diabetes mellitus (defined as "healthy" obese, DM-DL-); Group 2 subjects had only the presence of dyslipidemia (DM-DL+), while group 3 patients demonstrated the presence of both (DM + DL+). In all patients, we studied haematological, haemostasis, anaemia, coagulation plasma and trace elements parameters before and 1, 6 and 12 months after gastric bypass surgery. RESULTS: We found significant differences in some haematological parameters, including haemostasis (e.g., T-Quick, p = 0.0048) and coagulation (e.g., ATIII and PAI-1, p = 0.001 and p < 0.0001, respectively) and in anaemia parameters (e.g., folate, cobalamin and transferrin, p = 0.0002, p < 0.0001 and p = 0.0001, respectively) but also in serum trace elements between the groups. However, the response to bariatric surgery was similar in the three groups. CONCLUSION: Any healthy morbid obese subject is really metabolically "unhealthy" because he or she has many other haematologic or serum abnormalities that are often not included in the criteria for the definition of "healthy" in these obese subjects.
Authors: E Pardina; R Ferrer; J Rossell; D Ricart-Jané; K A Méndez-Lara; J A Baena-Fustegueras; A Lecube; J Julve; J Peinado-Onsurbe Journal: Int J Obes (Lond) Date: 2017-05-10 Impact factor: 5.095
Authors: Eva Pardina; Roser Ferrer; Joana Rossell; Juan Antonio Baena-Fustegueras; Albert Lecube; Jose Manuel Fort; Enric Caubet; Óscar González; Ramón Vilallonga; Víctor Vargas; José María Balibrea; Julia Peinado-Onsurbe Journal: BBA Clin Date: 2016-01-08