| Literature DB >> 24791731 |
Xue Zhang1, Yuncui Yu2, Jie Zhang3, Shengtian Huang1, Zhongzhan Wang1, Jianjun Zhang1, Yuxiang Yan3, Fen Liu4, Jianzhong Zhao5, Yan He6.
Abstract
In recent years, the number of breakthrough cases of varicella (onset >42 days after vaccination) increased each year, and varicella outbreaks continue to occur in Beijing. Data from the Immunization Information System and the Infectious Disease Reporting System demonstrated that in Beijing's Fengtai District, the varicella breakthrough rate increased from 0.7% in 2008 to 2.5% in 2012 and showed an increased trend (P<0.001). Among the varicella cases in children (age of 3-15 years), the number of breakthrough cases increased from 167 in 2008 to 622 in 2012, which was 45.2% (n=1735) of the total child cases (n=3842). From 2008 to 2012, a total of 62 outbreaks occurred; among the 787 affected child outbreak cases, 61% were vaccinated. Altogether, the results from this study indicated that 1-dose vaccination cannot sufficiently prevent the occurrence of breakthrough cases of varicella or control varicella outbreaks in Beijing's Fengtai District.Entities:
Keywords: Breakthrough; Epidemiology; Outbreak; Vaccination; Varicella
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Year: 2014 PMID： 24791731 DOI： 10.1016/j.vaccine.2014.04.069
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641