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Literature DB >> 24791688

The emerging role of exosomes in Wnt secretion and transport.

Abstract

Exosomes are small extracellular microvesicles that have an endosomal origin and are gaining increasing recognition for their important roles in mediating cell-cell communication. The content of exosomes includes a broad range of bioactive molecules, such as miRNA and signaling molecules that can mediate intercellular communication in various functional contexts. Recent studies have pointed to a critical role of exosomes in transmitting morphogen signaling during embryonic development and cancer progression. In this review we focus on recent progress that has revealed a role for exosomes in the secretion and processing of Wnt proteins, a family of morphogens with fundamental roles in homeostasis and cancer.

Entities: Disease

Mesh：

Substances：
Wnt Proteins

Year: 2014 PMID： 24791688 DOI： 10.1016/j.gde.2014.03.006

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

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Cited

35 in total

1. Microvesicle-mediated Wnt/β-Catenin Signaling Promotes Interspecies Mammary Stem/Progenitor Cell Growth.

Authors: Leen Bussche; Gat Rauner; Marc Antonyak; Bethany Syracuse; Melissa McDowell; Anthony M C Brown; Richard A Cerione; Gerlinde R Van de Walle
Journal: J Biol Chem Date: 2016-10-12 Impact factor: 5.157

2. Effect of pH on the isolation of urinary exosome.

Authors: Yao Zhao; Kaiyong Chen; Haining Li; Huiyi Wu
Journal: Int Urol Nephrol Date: 2016-09-27 Impact factor: 2.370

3. Loss of Endothelium-Derived Wnt5a Is Associated With Reduced Pericyte Recruitment and Small Vessel Loss in Pulmonary Arterial Hypertension.

Authors: Ke Yuan; Elya A Shamskhou; Mark E Orcholski; Abinaya Nathan; Sushma Reddy; Hiroaki Honda; Vigneshwaran Mani; Yitian Zeng; Mehmet O Ozen; Lingli Wang; Utkan Demirci; Wen Tian; Mark R Nicolls; Vinicio A de Jesus Perez
Journal: Circulation Date: 2019-04-02 Impact factor: 29.690

4. Allorecognition, via TgrB1 and TgrC1, mediates the transition from unicellularity to multicellularity in the social amoeba Dictyostelium discoideum.

Authors: Shigenori Hirose; Balaji Santhanam; Mariko Katoh-Kurosawa; Gad Shaulsky; Adam Kuspa
Journal: Development Date: 2015-09-22 Impact factor: 6.868

The emerging role of exosomes in Wnt secretion and transport.

1. Microvesicle-mediated Wnt/β-Catenin Signaling Promotes Interspecies Mammary Stem/Progenitor Cell Growth.

2. Effect of pH on the isolation of urinary exosome.

3. Loss of Endothelium-Derived Wnt5a Is Associated With Reduced Pericyte Recruitment and Small Vessel Loss in Pulmonary Arterial Hypertension.

4. Allorecognition, via TgrB1 and TgrC1, mediates the transition from unicellularity to multicellularity in the social amoeba Dictyostelium discoideum.

Review 5. Shedding light on the cell biology of extracellular vesicles.

6. Seeing is believing: Wnt3 localization in the gut epithelium.

7. Evidence of Extracellular Vesicles Biogenesis and Release in Mouse Embryonic Stem Cells.

Review 8. Extracellular vesicles round off communication in the nervous system.

9. Circulating microRNA Signatures in Rodent Models of Pain.

Review 10. Insights into the Critical Role of Exosomes in the Brain; from Neuronal Activity to Therapeutic Effects.