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Literature DB >> 24789765

Effects of Tet-induced oxidation products of 5-methylcytosine on Dnmt1- and DNMT3a-mediated cytosine methylation.

Debin Ji¹, Krystal Lin, Jikui Song, Yinsheng Wang.

Abstract

We investigated systematically the effects of Tet-induced oxidation products of 5-methylcytosine on Dnmt1- and DNMT3a-mediated cytosine methylation in synthetic duplex DNA. We found that the replacement of 5-methylcytosine at a CpG site with a 5-hydroxymethylcytosine, 5-formylcytosine, 5-carboxylcytosine or 5-hydroxymethyluracil resulted in altered methylation of cytosine at both the opposite and the neighboring CpG sites. Our results provided important new knowledge about the implications of the 5-methylcytosine oxidation products in maintenance cytosine methylation.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2014 PMID： 24789765 PMCID： PMC4052722 DOI： 10.1039/c4mb00150h

Source DB: PubMed Journal: Mol Biosyst ISSN： 1742-2051

25 in total

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Authors: Keith D Robertson
Journal: Nat Rev Genet Date: 2005-08 Impact factor: 53.242

2. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.

Authors: Yu-Fei He; Bin-Zhong Li; Zheng Li; Peng Liu; Yang Wang; Qingyu Tang; Jianping Ding; Yingying Jia; Zhangcheng Chen; Lin Li; Yan Sun; Xiuxue Li; Qing Dai; Chun-Xiao Song; Kangling Zhang; Chuan He; Guo-Liang Xu
Journal: Science Date: 2011-08-04 Impact factor: 47.728

3. Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development.

Authors: Azusa Inoue; Li Shen; Qing Dai; Chuan He; Yi Zhang
Journal: Cell Res Date: 2011-11-29 Impact factor: 25.617

4. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.

Authors: M Okano; D W Bell; D A Haber; E Li
Journal: Cell Date: 1999-10-29 Impact factor: 41.582

5. Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation.

Authors: Jikui Song; Olga Rechkoblit; Timothy H Bestor; Dinshaw J Patel
Journal: Science Date: 2010-12-16 Impact factor: 47.728

6. 6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.

Authors: Hongxia Wang; Yinsheng Wang
Journal: Biochemistry Date: 2009-03-17 Impact factor: 3.162

7. Potential functional roles of DNA demethylation intermediates.

Authors: Chun-Xiao Song; Chuan He
Journal: Trends Biochem Sci Date: 2013-08-08 Impact factor: 13.807

8. Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.

Authors: Liang Zhang; Xingyu Lu; Junyan Lu; Haihua Liang; Qing Dai; Guo-Liang Xu; Cheng Luo; Hualiang Jiang; Chuan He
Journal: Nat Chem Biol Date: 2012-02-12 Impact factor: 15.040

9. Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation.

Authors: Hideharu Hashimoto; Yiwei Liu; Anup K Upadhyay; Yanqi Chang; Shelley B Howerton; Paula M Vertino; Xing Zhang; Xiaodong Cheng
Journal: Nucleic Acids Res Date: 2012-02-22 Impact factor: 16.971

10. Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.

Authors: Solange Moréra; Inga Grin; Armelle Vigouroux; Sophie Couvé; Véronique Henriot; Murat Saparbaev; Alexander A Ishchenko
Journal: Nucleic Acids Res Date: 2012-07-30 Impact factor: 16.971

26 in total

1. Maintenance DNA Methyltransferase Activity in the Presence of Oxidized Forms of 5-Methylcytosine: Structural Basis for Ten Eleven Translocation-Mediated DNA Demethylation.

Authors: Christopher L Seiler; Jenna Fernandez; Zoe Koerperich; Molly P Andersen; Delshanee Kotandeniya; Megin E Nguyen; Yuk Y Sham; Natalia Y Tretyakova
Journal: Biochemistry Date: 2018-10-08 Impact factor: 3.162

Review 2. Active turnover of DNA methylation during cell fate decisions.

Authors: Aled Parry; Steffen Rulands; Wolf Reik
Journal: Nat Rev Genet Date: 2020-10-06 Impact factor: 53.242

Review 3. Uncovering epigenetic landscape: a new path for biomarkers identification and drug development.

Authors: Daiane Teixeira de Oliveira; Renata Guerra-Sá
Journal: Mol Biol Rep Date: 2020-10-21 Impact factor: 2.316

4. Can 5-methylcytosine analogues with extended alkyl side chains guide DNA methylation?

Authors: D Kotandeniya; C L Seiler; J Fernandez; S S Pujari; L Curwick; K Murphy; S Wickramaratne; S Yan; D Murphy; Yuk Y Sham; N Y Tretyakova
Journal: Chem Commun (Camb) Date: 2018-01-25 Impact factor: 6.222

5. Tet-Mediated DNA Demethylation Is Required for SWI/SNF-Dependent Chromatin Remodeling and Histone-Modifying Activities That Trigger Expression of the Sp7 Osteoblast Master Gene during Mesenchymal Lineage Commitment.

Authors: Hugo Sepulveda; Alejandro Villagra; Martin Montecino
Journal: Mol Cell Biol Date: 2017-09-26 Impact factor: 4.272

Review 6. 5-Hydroxymethylcytosine: a stable or transient DNA modification?

Authors: Maria A Hahn; Piroska E Szabó; Gerd P Pfeifer
Journal: Genomics Date: 2014-08-30 Impact factor: 5.736

7. X-ray irradiation induces subtle changes in the genome-wide distribution of DNA hydroxymethylation with opposing trends in genic and intergenic regions.

Authors: Benjamin V Becker; Leonhard Kaatsch; Richard Obermair; Gerrit Schrock; Matthias Port; Reinhard Ullmann
Journal: Epigenetics Date: 2019-01-29 Impact factor: 4.528