Literature DB >> 24788629

Chemical injury caused by acute alendronic acid aspiration.

Zoe Victoria Ottaway1, Cara Hammond, Simon Merritt.   

Abstract

A 79-year-old woman was prescribed bisphosphonates 3 years ago for osteoporosis. At the time of first prescription, she received counselling directions on how to take her medication, which she stringently adhered to. However, she accidentally aspirated an alendronic acid tablet and subsequently developed respiratory tract symptoms. An emergency bronchoscopy was performed. We describe the marked bronchoscopic changes following aspiration of alendronic acid.

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Year:  2014        PMID： 24788629      PMCID： PMC4009886          DOI： 10.1136/bcr-2013-200444

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  7 in total

1.  Aspiration of alendronic acid leading to localized bronchiectasis.

Authors:  Gordon I A MacDonald; Graeme P Currie; David M Reid
Journal:  Eur J Clin Pharmacol       Date:  2011-10-19       Impact factor: 2.953

2.  [Damage to the respiratory tract due to aspirated alendronate].

Authors:  S A Jungblut; H Frickmann; H J Achenbach; T O F Wagner
Journal:  Pneumologie       Date:  2007-10-10

3.  Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity.

Authors:  S Suri; J Mönkkönen; M Taskinen; J Pesonen; M A Blank; R J Phipps; M J Rogers
Journal:  Bone       Date:  2001-10       Impact factor: 4.398

4.  Effect of bisphosphonates on surface hydrophobicity and phosphatidylcholine concentration of rodent gastric mucosa.

Authors:  L M Lichtenberger; J J Romero; G W Gibson; M A Blank
Journal:  Dig Dis Sci       Date:  2000-09       Impact factor: 3.199

5.  Alendronate-induced esophagitis in an elderly woman.

Authors:  Victoria Gómez; Shu-Yuan Xiao
Journal:  Int J Clin Exp Pathol       Date:  2008-06-20

Review 6.  Esophagitis associated with the use of alendronate.

Authors:  P C de Groen; D F Lubbe; L J Hirsch; A Daifotis; W Stephenson; D Freedholm; S Pryor-Tillotson; M J Seleznick; H Pinkas; K K Wang
Journal:  N Engl J Med       Date:  1996-10-03       Impact factor: 91.245

7.  Esophageal irritation due to alendronate sodium tablets: possible mechanisms.

Authors:  C P Peter; L K Handt; S M Smith
Journal:  Dig Dis Sci       Date:  1998-09       Impact factor: 3.199
  7 in total

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