PURPOSE: We quantitatively investigated the peripapillary vascular morphology in patients with optic nerve head drusen (ONHD) and optic disc edema (ODE). METHODS: Computer-based fundus analysis was used to investigate peripapillary vascular morphology, including length, branching, and diameter of arteries and veins calibrated by optical coherence tomography. RESULTS: Patients with ONHD showed significantly larger diameters of arteries without branching (P = 0.05), and arteries after primary/before secondary branching (P = 0.04) and secondary venous branching started closer to the optic disc (P = 0.03) compared to healthy controls. The ODE patients had significantly reduced number of small peripapillary veins and larger number of veins without branching compared to ONHD and controls (P = 0.02). Anomalous branching with arterial and venous trifurcation presented in the ODE and ONHD groups, with significant higher prevalence in ODE patients for venous trifurcations compared to ONHD and controls (P = 0.02). CONCLUSIONS: The diameter of vessels in ONHD patients were significantly larger in arteries without branching (P = 0.05), after primary branching (P = 0.04), and venous branching closer to the disc area (P = 0.03) compared to controls. The ODE patients demonstrated widening of the small peripapillary veins measured by a significantly larger number of veins without branching (P = 0.001 and P = 0.02, compared to controls and ONHD, respectively) and less small veins (P = 0.001 and P = 0.04, compared to controls and ONHD, respectively). Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.
PURPOSE: We quantitatively investigated the peripapillary vascular morphology in patients with optic nerve head drusen (ONHD) and optic disc edema (ODE). METHODS: Computer-based fundus analysis was used to investigate peripapillary vascular morphology, including length, branching, and diameter of arteries and veins calibrated by optical coherence tomography. RESULTS:Patients with ONHD showed significantly larger diameters of arteries without branching (P = 0.05), and arteries after primary/before secondary branching (P = 0.04) and secondary venous branching started closer to the optic disc (P = 0.03) compared to healthy controls. The ODE patients had significantly reduced number of small peripapillary veins and larger number of veins without branching compared to ONHD and controls (P = 0.02). Anomalous branching with arterial and venous trifurcation presented in the ODE and ONHD groups, with significant higher prevalence in ODE patients for venous trifurcations compared to ONHD and controls (P = 0.02). CONCLUSIONS: The diameter of vessels in ONHD patients were significantly larger in arteries without branching (P = 0.05), after primary branching (P = 0.04), and venous branching closer to the disc area (P = 0.03) compared to controls. The ODE patients demonstrated widening of the small peripapillary veins measured by a significantly larger number of veins without branching (P = 0.001 and P = 0.02, compared to controls and ONHD, respectively) and less small veins (P = 0.001 and P = 0.04, compared to controls and ONHD, respectively). Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.