Naoto Yokogawa1, Scott M Lieberman2, Faizan Alawi1, Sharon Bout-Tabaku1, Marta Guttenberg1, David D Sherry1, Frederick B Vivino1. 1. From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children's Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania. 2. From the Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan; Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa, Iowa City, Iowa; Department of Dermatology, Division of Dermatopathology, and Division of Rheumatology, University of Pennsylvania, Philadelphia, Pennsylvania; Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio; Division of Anatomic Pathology, and the Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.N. Yokogawa, MD, Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center; S.M. Lieberman, MD, PhD, Stead Family Department of Pediatrics, Division of Rheumatology, Carver College of Medicine, University of Iowa; F. Alawi, DDS, Department of Dermatology, Division of Dermatopathology, University of Pennsylvania; S. Bout-Tabaku, MD, MSc, Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, Ohio State University College of Medicine; M. Guttenberg, MD, Division of Anatomic Pathology; D.D. Sherry, MD, Division of Rheumatology, The Children's Hospital of Philadelphia; F.B. Vivino, MD, MS, Division of Rheumatology, University of Pennsylvania. scott-lieberman@uiowa.edu.
Abstract
OBJECTIVE: To determine an appropriate focus score cutoff for childhood Sjögren syndrome (SS). METHODS: Labial salivary gland tissue from specimens from children with SS and age-matched controls was retrospectively identified and reviewed by a blinded oral pathologist. RESULTS: The presence of any focal sialadenitis (focus score > 0 foci/4 mm(2)) was common among childhood SS samples but present in only 1 of 8 control samples. CONCLUSION: The presence of any focal lymphocytic sialadenitis in minor labial salivary gland tissue is suggestive of childhood SS and should be included in future childhood SS-specific diagnostic or classification criteria.
OBJECTIVE: To determine an appropriate focus score cutoff for childhood Sjögren syndrome (SS). METHODS: Labial salivary gland tissue from specimens from children with SS and age-matched controls was retrospectively identified and reviewed by a blinded oral pathologist. RESULTS: The presence of any focal sialadenitis (focus score > 0 foci/4 mm(2)) was common among childhood SS samples but present in only 1 of 8 control samples. CONCLUSION: The presence of any focal lymphocytic sialadenitis in minor labial salivary gland tissue is suggestive of childhood SS and should be included in future childhood SS-specific diagnostic or classification criteria.
Entities:
Keywords:
DIAGNOSIS; MINOR SALIVARY GLANDS; PATHOLOGY; PEDIATRICS; SJÖGREN SYNDROME
Authors: Daniel S Hammenfors; Valéria Valim; Blanca E R G Bica; Sandra G Pasoto; Vibke Lilleby; Juan Carlos Nieto-González; Clovis A Silva; Esther Mossel; Rosa M R Pereira; Aline Coelho; Hendrika Bootsma; Akaluck Thatayatikom; Johan G Brun; Malin V Jonsson Journal: Arthritis Care Res (Hoboken) Date: 2019-12-10 Impact factor: 4.794